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Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

Research output: Contribution to journalReview article

Original languageEnglish
Article numbere1395127
Pages (from-to)e1395127-e1395127-11
Number of pages12
JournalOncoImmunology
Volume7
Issue number3
Early online date20 Nov 2017
DOIs
Publication statusPublished - 2018

Documents

  • Antibody structure and engineering_HOFFMAN_Publishedonline20November2017_GOLD VoR (CC BY)

    Hoffmann_et_al_OncoImmunology_ADC_2018.pdf, 1.08 MB, application/pdf

    6/02/2018

    Final published version

    CC BY

    This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

King's Authors

Abstract

Antibody-drug conjugates (ADCs) are emerging as effective tools in cancer therapy, combining the antibody's exquisite specificity for the target antigen-expressing cancer cell together with the cytotoxic potency of the payload. Much success stems from the rational design of "toxic warheads", chemically linked to antibodies, and from fine-tuning the intricate properties of chemical linkers. Here, we focus on the antibody moiety of ADCs, dissecting the impact of Fab, linkers, isotype and Fc structure on the anti-tumoral and immune-activating functions of ADCs. Novel design approaches informed by antibody structural attributes present opportunities that may contribute to the success of next generation ADCs.

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