Antihypertensive treatment after first stroke in primary care: results from the General Practitioner Research Database

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Abstract

Objectives Secondary stroke prevention guidelines emphasize antihypertensive treatment (AHT). Routine data on recommended AHT are lacking. Aim To estimate the use of any antihypertensive and guideline-recommended antihypertensive use in first ever stroke patients and their effects on survival and recurrence after 1 year in an unbiased population. Methods The General Practitioner Research Database (GPRD) contains primary care information across the UK. Forty-eight thousand two hundred and thirty-nine registered patients with first stroke between 1997 and 2006 were identified. Guideline AHT was defined based on guidelines of the British Hypertension Society. The impact of AHT on survival or recurrence-free survival was estimated using Cox regression adjusting for treatment propensity scores. Results AHT was prescribed to 75% of hypertensive stroke patients surviving 3 months after stroke, increasing from 66% in 1997 to 83% in 2006 (P
Original languageEnglish
Pages (from-to)154 - 160
Number of pages7
JournalJournal of Hypertension
Volume29
Issue number1
DOIs
Publication statusPublished - Jan 2011

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