Antimalarial ethnobotany: In vitro antiplasmodial activity of seven plants identified in the Nigerian Middle Belt

E Ajaiyeoba; J Ashidi; O Abiodun; L Okpako; O Ogbole; D Akinboye; C Falade; O Bolaji; G Gbotosho; M Falade; O Itiola; P Houghton; C Wright; A Oduola

doi:10.1080/13880200490902455

Antimalarial ethnobotany: In vitro antiplasmodial activity of seven plants identified in the Nigerian Middle Belt

E Ajaiyeoba, J Ashidi, O Abiodun, L Okpako, O Ogbole, D Akinboye, C Falade, O Bolaji, G Gbotosho, M Falade, O Itiola, P Houghton, C Wright, A Oduola

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Abstract

Seven methanol extracts of seven plants from seven plant families were screened for antimalarial properties. The plants were identified and selected from Gboko and Kastina-Ala local government areas in the Tivland ethnobotany in the Middle Belt Zone of Nigeria. Methanol plant extracts were evaluated for in vitro antimalarial properties using the lactate dehydrogenase technique, with a multiresistant strain of Plasmodium falciparum K1. Quantification of activity was by estimation of the concentration of extracts that inhibited 50% growth of parasite (IC50) in [mu]g/ml. Of the seven plants screened, Erythrina senegalensis DC (Leguminosae), Pericopsis elata Harms (Papilionaceae), and Bridelia micrantha Benth (Fabaceae) had IC50 values of 99.7, 124.8, and 158.7 [mu]g/ml, respectively. Nauclea latifolia SM (Rubiaceae) extract exhibited the least activity in the assay with an IC50 value of 478.9 [mu]g/ml. (C) 2004 Taylor & Francis Ltd.

Original language	English
Pages (from-to)	588 - 591
Number of pages	4
Journal	PHARMACEUTICAL BIOLOGY
Volume	42
Issue number	8
DOIs	https://doi.org/10.1080/13880200490902455
Publication status	Published - Dec 2004

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Ajaiyeoba, E., Ashidi, J., Abiodun, O., Okpako, L., Ogbole, O., Akinboye, D., Falade, C., Bolaji, O., Gbotosho, G., Falade, M., Itiola, O., Houghton, P., Wright, C., & Oduola, A. (2004). Antimalarial ethnobotany: In vitro antiplasmodial activity of seven plants identified in the Nigerian Middle Belt. PHARMACEUTICAL BIOLOGY, 42(8), 588 - 591. https://doi.org/10.1080/13880200490902455

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title = "Antimalarial ethnobotany: In vitro antiplasmodial activity of seven plants identified in the Nigerian Middle Belt",

abstract = "Seven methanol extracts of seven plants from seven plant families were screened for antimalarial properties. The plants were identified and selected from Gboko and Kastina-Ala local government areas in the Tivland ethnobotany in the Middle Belt Zone of Nigeria. Methanol plant extracts were evaluated for in vitro antimalarial properties using the lactate dehydrogenase technique, with a multiresistant strain of Plasmodium falciparum K1. Quantification of activity was by estimation of the concentration of extracts that inhibited 50% growth of parasite (IC50) in [mu]g/ml. Of the seven plants screened, Erythrina senegalensis DC (Leguminosae), Pericopsis elata Harms (Papilionaceae), and Bridelia micrantha Benth (Fabaceae) had IC50 values of 99.7, 124.8, and 158.7 [mu]g/ml, respectively. Nauclea latifolia SM (Rubiaceae) extract exhibited the least activity in the assay with an IC50 value of 478.9 [mu]g/ml. (C) 2004 Taylor & Francis Ltd.",

author = "E Ajaiyeoba and J Ashidi and O Abiodun and L Okpako and O Ogbole and D Akinboye and C Falade and O Bolaji and G Gbotosho and M Falade and O Itiola and P Houghton and C Wright and A Oduola",

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Ajaiyeoba, E, Ashidi, J, Abiodun, O, Okpako, L, Ogbole, O, Akinboye, D, Falade, C, Bolaji, O, Gbotosho, G, Falade, M, Itiola, O, Houghton, P, Wright, C & Oduola, A 2004, 'Antimalarial ethnobotany: In vitro antiplasmodial activity of seven plants identified in the Nigerian Middle Belt', PHARMACEUTICAL BIOLOGY, vol. 42, no. 8, pp. 588 - 591. https://doi.org/10.1080/13880200490902455

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T1 - Antimalarial ethnobotany: In vitro antiplasmodial activity of seven plants identified in the Nigerian Middle Belt

AU - Ajaiyeoba, E

AU - Ashidi, J

AU - Abiodun, O

AU - Okpako, L

AU - Ogbole, O

AU - Akinboye, D

AU - Falade, C

AU - Bolaji, O

AU - Gbotosho, G

AU - Falade, M

AU - Itiola, O

AU - Houghton, P

AU - Wright, C

AU - Oduola, A

PY - 2004/12

Y1 - 2004/12

N2 - Seven methanol extracts of seven plants from seven plant families were screened for antimalarial properties. The plants were identified and selected from Gboko and Kastina-Ala local government areas in the Tivland ethnobotany in the Middle Belt Zone of Nigeria. Methanol plant extracts were evaluated for in vitro antimalarial properties using the lactate dehydrogenase technique, with a multiresistant strain of Plasmodium falciparum K1. Quantification of activity was by estimation of the concentration of extracts that inhibited 50% growth of parasite (IC50) in [mu]g/ml. Of the seven plants screened, Erythrina senegalensis DC (Leguminosae), Pericopsis elata Harms (Papilionaceae), and Bridelia micrantha Benth (Fabaceae) had IC50 values of 99.7, 124.8, and 158.7 [mu]g/ml, respectively. Nauclea latifolia SM (Rubiaceae) extract exhibited the least activity in the assay with an IC50 value of 478.9 [mu]g/ml. (C) 2004 Taylor & Francis Ltd.

AB - Seven methanol extracts of seven plants from seven plant families were screened for antimalarial properties. The plants were identified and selected from Gboko and Kastina-Ala local government areas in the Tivland ethnobotany in the Middle Belt Zone of Nigeria. Methanol plant extracts were evaluated for in vitro antimalarial properties using the lactate dehydrogenase technique, with a multiresistant strain of Plasmodium falciparum K1. Quantification of activity was by estimation of the concentration of extracts that inhibited 50% growth of parasite (IC50) in [mu]g/ml. Of the seven plants screened, Erythrina senegalensis DC (Leguminosae), Pericopsis elata Harms (Papilionaceae), and Bridelia micrantha Benth (Fabaceae) had IC50 values of 99.7, 124.8, and 158.7 [mu]g/ml, respectively. Nauclea latifolia SM (Rubiaceae) extract exhibited the least activity in the assay with an IC50 value of 478.9 [mu]g/ml. (C) 2004 Taylor & Francis Ltd.

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DO - 10.1080/13880200490902455

M3 - Article

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EP - 591

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JF - PHARMACEUTICAL BIOLOGY

IS - 8

ER -

Antimalarial ethnobotany: In vitro antiplasmodial activity of seven plants identified in the Nigerian Middle Belt

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