Antimicrobial activities of a new schizozygane indoline alkaloid from Schizozygia coffaeoides and the revised structure of isoschizogaline

R M Kariba; P J Houghton; A Yenesew

doi:10.1021/np010298m

Antimicrobial activities of a new schizozygane indoline alkaloid from Schizozygia coffaeoides and the revised structure of isoschizogaline

R M Kariba, P J Houghton, A Yenesew

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92 Citations (Scopus)

Abstract

Extracts from Schizozygia coffaeoides showed antimicrobial activity against fungal and bacterial species. Alkaloids isolated using bioassay-guided fractionation were isoschizogaline, schizogynine, and a new indoline alkaloid, 7,8-dehydro-19/3-hydroxyschizozygine, shown to be the most active antifungal compound. The structure of isoschizagaline, the only active antibacterial, is revised on the basis of NMR analysis.

Original language	English
Pages (from-to)	566 - 569
Number of pages	4
Journal	Journal of Natural Products
Volume	65
Issue number	4
DOIs	https://doi.org/10.1021/np010298m
Publication status	Published - 2002

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abstract = "Extracts from Schizozygia coffaeoides showed antimicrobial activity against fungal and bacterial species. Alkaloids isolated using bioassay-guided fractionation were isoschizogaline, schizogynine, and a new indoline alkaloid, 7,8-dehydro-19/3-hydroxyschizozygine, shown to be the most active antifungal compound. The structure of isoschizagaline, the only active antibacterial, is revised on the basis of NMR analysis.",

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AU - Yenesew, A

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AB - Extracts from Schizozygia coffaeoides showed antimicrobial activity against fungal and bacterial species. Alkaloids isolated using bioassay-guided fractionation were isoschizogaline, schizogynine, and a new indoline alkaloid, 7,8-dehydro-19/3-hydroxyschizozygine, shown to be the most active antifungal compound. The structure of isoschizagaline, the only active antibacterial, is revised on the basis of NMR analysis.

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Antimicrobial activities of a new schizozygane indoline alkaloid from Schizozygia coffaeoides and the revised structure of isoschizogaline

Abstract

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