Antiretrovirals and the kidney in current clinical practice: renal pharmacokinetics, alterations of renal function and renal toxicity

Jean C. Yombi; Anton Pozniak; Marta Boffito; Rachael Jones; Saye Khoo; Jeremy Levy; Frank A. Post

doi:10.1097/QAD.0000000000000103

Antiretrovirals and the kidney in current clinical practice: renal pharmacokinetics, alterations of renal function and renal toxicity

Jean C. Yombi, Anton Pozniak, Marta Boffito, Rachael Jones, Saye Khoo, Jeremy Levy, Frank A. Post^*

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

89 Citations (Scopus)

Abstract

Assessment of renal function in HIV-positive patients is of increasing importance in the context of ageing and associated comorbidities. Exposure to nephrotoxic medications is widespread, and several commonly used antiretroviral drugs have nephrotoxic potential. Moreover, specific antiretrovirals inhibit renal tubular transporters resulting in the potential for drug-drug interactions as well as increases in serum creatinine concentrations, which affect estimates of glomerular filtration rate in the absence of changes in actual glomerular filtration rate. This review explores the effects of antiretroviral therapy on the kidney and offers an understanding of mechanisms that lead to apparent and real changes in renal function.

Original language	English
Pages (from-to)	621-632
Number of pages	12
Journal	Aids
Volume	28
Issue number	5
DOIs	https://doi.org/10.1097/QAD.0000000000000103
Publication status	Published - 13 Mar 2014

Keywords

pharmacokinetics
therapy
HIV
estimated glomerular filtration rate
kidney
transporters
HIV-INFECTED PATIENTS
RITONAVIR-BOOSTED ATAZANAVIR
GLOMERULAR-FILTRATION-RATE
TENOFOVIR DISOPROXIL FUMARATE
ACUTE INTERSTITIAL NEPHRITIS
CO-FORMULATED ELVITEGRAVIR
NON-INFERIORITY TRIAL
DOUBLE-BLIND
INITIAL TREATMENT
DRUG-INTERACTIONS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/QAD.0000000000000103

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title = "Antiretrovirals and the kidney in current clinical practice: renal pharmacokinetics, alterations of renal function and renal toxicity",

abstract = "Assessment of renal function in HIV-positive patients is of increasing importance in the context of ageing and associated comorbidities. Exposure to nephrotoxic medications is widespread, and several commonly used antiretroviral drugs have nephrotoxic potential. Moreover, specific antiretrovirals inhibit renal tubular transporters resulting in the potential for drug-drug interactions as well as increases in serum creatinine concentrations, which affect estimates of glomerular filtration rate in the absence of changes in actual glomerular filtration rate. This review explores the effects of antiretroviral therapy on the kidney and offers an understanding of mechanisms that lead to apparent and real changes in renal function.",

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author = "Yombi, {Jean C.} and Anton Pozniak and Marta Boffito and Rachael Jones and Saye Khoo and Jeremy Levy and Post, {Frank A.}",

year = "2014",

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doi = "10.1097/QAD.0000000000000103",

language = "English",

volume = "28",

pages = "621--632",

journal = "Aids",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Antiretrovirals and the kidney in current clinical practice

T2 - renal pharmacokinetics, alterations of renal function and renal toxicity

AU - Yombi, Jean C.

AU - Pozniak, Anton

AU - Boffito, Marta

AU - Jones, Rachael

AU - Khoo, Saye

AU - Levy, Jeremy

AU - Post, Frank A.

PY - 2014/3/13

Y1 - 2014/3/13

N2 - Assessment of renal function in HIV-positive patients is of increasing importance in the context of ageing and associated comorbidities. Exposure to nephrotoxic medications is widespread, and several commonly used antiretroviral drugs have nephrotoxic potential. Moreover, specific antiretrovirals inhibit renal tubular transporters resulting in the potential for drug-drug interactions as well as increases in serum creatinine concentrations, which affect estimates of glomerular filtration rate in the absence of changes in actual glomerular filtration rate. This review explores the effects of antiretroviral therapy on the kidney and offers an understanding of mechanisms that lead to apparent and real changes in renal function.

AB - Assessment of renal function in HIV-positive patients is of increasing importance in the context of ageing and associated comorbidities. Exposure to nephrotoxic medications is widespread, and several commonly used antiretroviral drugs have nephrotoxic potential. Moreover, specific antiretrovirals inhibit renal tubular transporters resulting in the potential for drug-drug interactions as well as increases in serum creatinine concentrations, which affect estimates of glomerular filtration rate in the absence of changes in actual glomerular filtration rate. This review explores the effects of antiretroviral therapy on the kidney and offers an understanding of mechanisms that lead to apparent and real changes in renal function.

KW - pharmacokinetics

KW - therapy

KW - HIV

KW - estimated glomerular filtration rate

KW - kidney

KW - transporters

KW - HIV-INFECTED PATIENTS

KW - RITONAVIR-BOOSTED ATAZANAVIR

KW - GLOMERULAR-FILTRATION-RATE

KW - TENOFOVIR DISOPROXIL FUMARATE

KW - ACUTE INTERSTITIAL NEPHRITIS

KW - CO-FORMULATED ELVITEGRAVIR

KW - NON-INFERIORITY TRIAL

KW - DOUBLE-BLIND

KW - INITIAL TREATMENT

KW - DRUG-INTERACTIONS

U2 - 10.1097/QAD.0000000000000103

DO - 10.1097/QAD.0000000000000103

M3 - Literature review

SN - 0269-9370

VL - 28

SP - 621

EP - 632

JO - Aids

JF - Aids

IS - 5

ER -

Antiretrovirals and the kidney in current clinical practice: renal pharmacokinetics, alterations of renal function and renal toxicity

Abstract

Keywords

UN SDGs

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