Antitumour activity of enzalutamide (MDV3100) in patients with metastatic castration-resistant prostate cancer (CRPC) pre-treated with docetaxel and abiraterone

D. Bianchini, D. Lorente, A. Rodriguez-Vida, A. Omlin, C. Pezaro, R. Ferraldeschi, A. Zivi, G. Attard, Simon Chowdhury, J. S. de Bono*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    182 Citations (Scopus)

    Abstract

    Background: The new generation anti-androgen enzalutamide and the potent CYP17 inhibitor abiraterone have both demonstrated survival benefits in patients with metastatic castration-resistant prostate cancer (CRPC) progressing after docetaxel. Preliminary data on the antitumour activity of abiraterone after enzalutamide have suggested limited activity. The antitumour activity and safety of enzalutamide after abiraterone in metastatic CRPC patients is still unknown.

    Patients and Methods: We retrospectively identified patients treated with docetaxel and abiraterone prior to enzalutamide to investigate the activity and safety of enzalutamide in a more advanced setting. Prostate specific antigen (PSA), radiological and clinical assessments were analysed.

    Results: 39 patients with metastatic CRPC were identified for this analysis (median age 70 years, range: 54-85 years). Overall 16 patients (41%) had a confirmed PSA decline of at least 30%. Confirmed PSA declines of >= 50% and >= 90% were achieved in 5/39 (12.8%) and 1/39 (2.5%) respectively. Of the 15 patients who responded to abiraterone, two (13.3%) also had a confirmed >= 50% PSA decline on subsequent enzalutamide. Among the 22 abiraterone-refractory patients, two (9%) achieved a confirmed >= 50% PSA decline on enzalutamide.

    Conclusion: Our preliminary case series data suggest limited activity of enzalutamide in the post-docetaxel and post-abiraterone patient population. 

    Original languageEnglish
    Pages (from-to)78-84
    Number of pages7
    JournalEuropean Journal of Cancer
    Volume50
    Issue number1
    DOIs
    Publication statusPublished - Jan 2014

    Keywords

    • Abiraterone
    • Enzalutamide
    • Castration resistant prostate cancer
    • Hormone therapy
    • Androgen receptor targeting
    • ANDROGEN RECEPTOR
    • INCREASED SURVIVAL
    • ACETATE
    • CELLS

    Cite this