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Antitussive therapy: A role for levodropropizine

Research output: Contribution to journalReview article

Surinder Birring, Francesco de Blasio, Peter V. Dicpinigaitis, Giovanni Fontana, Luigi Lanata, Clive Page, Federico Saibene, Alessandro Zanasi

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalPulmonary Pharmacology and Therapeutics
Volume56
DOIs
Publication statusPublished - 1 Jun 2019

King's Authors

Abstract

Cough is a protective reflex that serves to clear the airways of excessive secretions and foreign matter and which sometimes becomes excessive, and troublesome to patients. Cough is one of the most common reasons why individuals seek medical attention. A range of drugs have been developed in the past with antitussive activity and different mechanisms of action, but there are still very few safe and effective treatments available. The poor tolerability of most available antitussives is closely related to their action on the central nervous system (CNS). An international group of experts specialized in cough met to discuss the need to identify an effective antitussive treatment with a good tolerability profile. The aim of this expert review is to increase the knowledge about the cough mechanism and the activity of levodropropizine, a peripherally acting antitussive drug.

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