Antiviral Inhibition of Enveloped Virus Release by Tetherin/BST-2: Action and Counteraction

Research output: Contribution to journalLiterature reviewpeer-review

75 Citations (Scopus)

Abstract

Tetherin (BST2/CD317) has been recently recognized as a potent interferon-induced antiviral molecule that inhibits the release of diverse mammalian enveloped virus particles from infected cells. By targeting an immutable structure common to all these viruses, the virion membrane, evasion of this antiviral mechanism has necessitated the development of specific countermeasures that directly inhibit tetherin activity. Here we review our current understanding of the molecular basis of tetherin's mode of action, the viral countermeasures that antagonize it, and how virus/tetherin interactions may affect viral transmission and pathogenicity.
Original languageEnglish
Pages (from-to)520-540
Number of pages21
JournalViruses-Basel
Volume3
Issue number5
DOIs
Publication statusPublished - 6 May 2011

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