Research output: Contribution to journal › Article
Kerstin Klaser, Ellen J Thompson, Long H Nguyen, Carole H Sudre, Michela Antonelli, Benjamin Murray, Liane S Canas, Erika Molteni, Mark S Graham, Eric Kerfoot, Liyuan Chen, Jie Deng, Anna May, Christina Hu, Andy Guest, Somesh Selvachandran, David A Drew, Marc Modat, Andrew T Chan, Jonathan Wolf & 5 more
Original language | English |
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Pages (from-to) | 1254-1258 |
Number of pages | 5 |
Journal | Journal of Neurology, Neurosurgery and Psychiatry |
Volume | 92 |
Issue number | 12 |
Early online date | 28 Sep 2021 |
DOIs | |
Accepted/In press | 7 Sep 2021 |
E-pub ahead of print | 28 Sep 2021 |
Published | 16 Nov 2021 |
Additional links |
BACKGROUND: Mental health issues have been reported after SARS-CoV-2 infection. However, comparison to prevalence in uninfected individuals and contribution from common risk factors (eg, obesity and comorbidities) have not been examined. We identified how COVID-19 relates to mental health in the large community-based COVID Symptom Study. METHODS: We assessed anxiety and depression symptoms using two validated questionnaires in 413148 individuals between February and April 2021; 26998 had tested positive for SARS-CoV-2. We adjusted for physical and mental prepandemic comorbidities, body mass index (BMI), age and sex. FINDINGS: Overall, 26.4% of participants met screening criteria for general anxiety and depression. Anxiety and depression were slightly more prevalent in previously SARS-CoV-2-positive (30.4%) vs SARS-CoV-2-negative (26.1%) individuals. This association was small compared with the effect of an unhealthy BMI and the presence of other comorbidities, and not evident in younger participants (≤40 years). Findings were robust to multiple sensitivity analyses. Association between SARS-CoV-2 infection and anxiety and depression was stronger in individuals with recent (<30 days) versus more distant (>120 days) infection, suggesting a short-term effect. INTERPRETATION: A small association was identified between SARS-CoV-2 infection and anxiety and depression symptoms. The proportion meeting criteria for self-reported anxiety and depression disorders is only slightly higher than prepandemic.
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