Anxiety mediates the relationship between interpretation bias and paranoia in patients with persistent persecutory beliefs

TY - JOUR

T1 - Anxiety mediates the relationship between interpretation bias and paranoia in patients with persistent persecutory beliefs

AU - Lam, Charlene L.M.

AU - Mouchlianitis, Elias

AU - Lee, Tatia M.C.

AU - Yiend, Jenny

PY - 2021/8/11

Y1 - 2021/8/11

N2 - Background and Objectives: The role of interpretation bias in generating and maintaining persecutory beliefs/paranoid ideation is becoming established in the literature, but how negative mood affects this relationship remains unclear. The current study investigated the mediating role of anxiety and depression in the association between interpretation bias and paranoia in patients with persistent paranoia. Methods/Design: We applied the mediation model to clinical data gathered from patients with persistent paranoia (N = 62), and compared how levels of depression and anxiety affected the association between interpretation bias and paranoia. Results: Interpretation bias and anxiety accounted for 43% of the variance in paranoia, while interpretation bias and depression explained 31% of this variance. Levels of anxiety, but not depression, partially mediated the relationship between interpretation bias and paranoid beliefs. Our data suggest that the association between interpretation bias and paranoid beliefs takes effect partly, although not completely, through heightened levels of anxiety. Conclusions: The current study highlighted the role of anxiety as a mediator in the association between interpretation bias and paranoid beliefs in patients with distressing paranoia. These findings inform the potential mechanism underlying cognitive interventions for pathological paranoia. Trial registration: Current Controlled Trials ISRCTN: 90749868. Retrospectively registered on 12 May 2016.

AB - Background and Objectives: The role of interpretation bias in generating and maintaining persecutory beliefs/paranoid ideation is becoming established in the literature, but how negative mood affects this relationship remains unclear. The current study investigated the mediating role of anxiety and depression in the association between interpretation bias and paranoia in patients with persistent paranoia. Methods/Design: We applied the mediation model to clinical data gathered from patients with persistent paranoia (N = 62), and compared how levels of depression and anxiety affected the association between interpretation bias and paranoia. Results: Interpretation bias and anxiety accounted for 43% of the variance in paranoia, while interpretation bias and depression explained 31% of this variance. Levels of anxiety, but not depression, partially mediated the relationship between interpretation bias and paranoid beliefs. Our data suggest that the association between interpretation bias and paranoid beliefs takes effect partly, although not completely, through heightened levels of anxiety. Conclusions: The current study highlighted the role of anxiety as a mediator in the association between interpretation bias and paranoid beliefs in patients with distressing paranoia. These findings inform the potential mechanism underlying cognitive interventions for pathological paranoia. Trial registration: Current Controlled Trials ISRCTN: 90749868. Retrospectively registered on 12 May 2016.

KW - anxiety

KW - depression

KW - Interpretation bias

KW - paranoia

UR - http://www.scopus.com/inward/record.url?scp=85089445909&partnerID=8YFLogxK

U2 - 10.1080/10615806.2020.1802435

DO - 10.1080/10615806.2020.1802435

M3 - Article

AN - SCOPUS:85089445909

SN - 1061-5806

VL - 34

SP - 96

EP - 106

JO - Anxiety, Stress and Coping

JF - Anxiety, Stress and Coping

IS - 1

ER -