King's College London

Research portal

APOE epsilon 2 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes

Research output: Contribution to journalArticle

Yawu Liu, Teemu Paajanen, Eric Westman, Yi Zhang, Lars-Olof Wahlund, Andrew Simmons, Catherine Tunnard, Tomasz Sobow, Petroula Proitsi, John Powell, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Sebastian Muehlboeck, Alan Evans, Christian Spenger, Simon Lovestone, Hilkka Soininen

Original languageEnglish
Pages (from-to)229 - 237
Number of pages9
JournalDementia and Geriatric Cognitive Disorders
Issue number3
Publication statusPublished - Oct 2010

King's Authors


Background: The protective effect of the apolipoprotein E (APOE) epsilon 2 allele against Alzheimer's disease (AD) is controversial. Objective: Our purpose was to clarify if the epsilon 2 allele affects regional cortical thicknesses and volumes. Methods: Regional cortical thicknesses and volumes were measured with an automated pipeline in 109 subjects with mild cognitive impairment, 114 AD patients and 105 age-matched healthy controls. Results: In the mild cognitive impairment group, the epsilon 2 carriers had thicker regional cortices at the transverse temporal cortex and parahippocampal gyrus than the subjects with epsilon 3/epsilon 3, and a larger cerebral gray matter and smaller lateral ventricles than the epsilon 3/epsilon 3 and epsilon 4 carriers. In the AD group, the epsilon 2 carriers had significantly thicker entorhinal and transverse temporal cortices, a larger whole cerebral gray matter, and smaller lateral ventricles than the subjects with the epsilon 3/epsilon 3 genotype, and a significantly thicker entorhinal cortex and larger cerebral gray matter than epsilon 4 carriers. No APOE2 effect was found in the control group. Conclusion: The APOE epsilon 2 allele is associated with larger regional cortical thicknesses and volumes in mild cognitive impairment and AD. Copyright (C) 2010 S. Karger AG, Basel

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454