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APOE epsilon 2 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes

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APOE epsilon 2 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes. / Liu, Yawu; Paajanen, Teemu; Westman, Eric; Zhang, Yi; Wahlund, Lars-Olof; Simmons, Andrew; Tunnard, Catherine; Sobow, Tomasz; Proitsi, Petroula; Powell, John; Mecocci, Patrizia; Tsolaki, Magda; Vellas, Bruno; Muehlboeck, Sebastian; Evans, Alan; Spenger, Christian; Lovestone, Simon; Soininen, Hilkka.

In: Dementia and Geriatric Cognitive Disorders, Vol. 30, No. 3, 10.2010, p. 229 - 237.

Research output: Contribution to journalArticle

Harvard

Liu, Y, Paajanen, T, Westman, E, Zhang, Y, Wahlund, L-O, Simmons, A, Tunnard, C, Sobow, T, Proitsi, P, Powell, J, Mecocci, P, Tsolaki, M, Vellas, B, Muehlboeck, S, Evans, A, Spenger, C, Lovestone, S & Soininen, H 2010, 'APOE epsilon 2 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes', Dementia and Geriatric Cognitive Disorders, vol. 30, no. 3, pp. 229 - 237. https://doi.org/10.1159/000320136

APA

Liu, Y., Paajanen, T., Westman, E., Zhang, Y., Wahlund, L-O., Simmons, A., ... Soininen, H. (2010). APOE epsilon 2 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes. Dementia and Geriatric Cognitive Disorders, 30(3), 229 - 237. https://doi.org/10.1159/000320136

Vancouver

Liu Y, Paajanen T, Westman E, Zhang Y, Wahlund L-O, Simmons A et al. APOE epsilon 2 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes. Dementia and Geriatric Cognitive Disorders. 2010 Oct;30(3):229 - 237. https://doi.org/10.1159/000320136

Author

Liu, Yawu ; Paajanen, Teemu ; Westman, Eric ; Zhang, Yi ; Wahlund, Lars-Olof ; Simmons, Andrew ; Tunnard, Catherine ; Sobow, Tomasz ; Proitsi, Petroula ; Powell, John ; Mecocci, Patrizia ; Tsolaki, Magda ; Vellas, Bruno ; Muehlboeck, Sebastian ; Evans, Alan ; Spenger, Christian ; Lovestone, Simon ; Soininen, Hilkka. / APOE epsilon 2 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes. In: Dementia and Geriatric Cognitive Disorders. 2010 ; Vol. 30, No. 3. pp. 229 - 237.

Bibtex Download

@article{2cbe2a39b0c840f6b19452270a0b66ae,
title = "APOE epsilon 2 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes",
abstract = "Background: The protective effect of the apolipoprotein E (APOE) epsilon 2 allele against Alzheimer's disease (AD) is controversial. Objective: Our purpose was to clarify if the epsilon 2 allele affects regional cortical thicknesses and volumes. Methods: Regional cortical thicknesses and volumes were measured with an automated pipeline in 109 subjects with mild cognitive impairment, 114 AD patients and 105 age-matched healthy controls. Results: In the mild cognitive impairment group, the epsilon 2 carriers had thicker regional cortices at the transverse temporal cortex and parahippocampal gyrus than the subjects with epsilon 3/epsilon 3, and a larger cerebral gray matter and smaller lateral ventricles than the epsilon 3/epsilon 3 and epsilon 4 carriers. In the AD group, the epsilon 2 carriers had significantly thicker entorhinal and transverse temporal cortices, a larger whole cerebral gray matter, and smaller lateral ventricles than the subjects with the epsilon 3/epsilon 3 genotype, and a significantly thicker entorhinal cortex and larger cerebral gray matter than epsilon 4 carriers. No APOE2 effect was found in the control group. Conclusion: The APOE epsilon 2 allele is associated with larger regional cortical thicknesses and volumes in mild cognitive impairment and AD. Copyright (C) 2010 S. Karger AG, Basel",
author = "Yawu Liu and Teemu Paajanen and Eric Westman and Yi Zhang and Lars-Olof Wahlund and Andrew Simmons and Catherine Tunnard and Tomasz Sobow and Petroula Proitsi and John Powell and Patrizia Mecocci and Magda Tsolaki and Bruno Vellas and Sebastian Muehlboeck and Alan Evans and Christian Spenger and Simon Lovestone and Hilkka Soininen",
year = "2010",
month = "10",
doi = "10.1159/000320136",
language = "English",
volume = "30",
pages = "229 -- 237",
journal = "Dementia and Geriatric Cognitive Disorders",
issn = "1420-8008",
publisher = "S. Karger AG",
number = "3",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - APOE epsilon 2 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes

AU - Liu, Yawu

AU - Paajanen, Teemu

AU - Westman, Eric

AU - Zhang, Yi

AU - Wahlund, Lars-Olof

AU - Simmons, Andrew

AU - Tunnard, Catherine

AU - Sobow, Tomasz

AU - Proitsi, Petroula

AU - Powell, John

AU - Mecocci, Patrizia

AU - Tsolaki, Magda

AU - Vellas, Bruno

AU - Muehlboeck, Sebastian

AU - Evans, Alan

AU - Spenger, Christian

AU - Lovestone, Simon

AU - Soininen, Hilkka

PY - 2010/10

Y1 - 2010/10

N2 - Background: The protective effect of the apolipoprotein E (APOE) epsilon 2 allele against Alzheimer's disease (AD) is controversial. Objective: Our purpose was to clarify if the epsilon 2 allele affects regional cortical thicknesses and volumes. Methods: Regional cortical thicknesses and volumes were measured with an automated pipeline in 109 subjects with mild cognitive impairment, 114 AD patients and 105 age-matched healthy controls. Results: In the mild cognitive impairment group, the epsilon 2 carriers had thicker regional cortices at the transverse temporal cortex and parahippocampal gyrus than the subjects with epsilon 3/epsilon 3, and a larger cerebral gray matter and smaller lateral ventricles than the epsilon 3/epsilon 3 and epsilon 4 carriers. In the AD group, the epsilon 2 carriers had significantly thicker entorhinal and transverse temporal cortices, a larger whole cerebral gray matter, and smaller lateral ventricles than the subjects with the epsilon 3/epsilon 3 genotype, and a significantly thicker entorhinal cortex and larger cerebral gray matter than epsilon 4 carriers. No APOE2 effect was found in the control group. Conclusion: The APOE epsilon 2 allele is associated with larger regional cortical thicknesses and volumes in mild cognitive impairment and AD. Copyright (C) 2010 S. Karger AG, Basel

AB - Background: The protective effect of the apolipoprotein E (APOE) epsilon 2 allele against Alzheimer's disease (AD) is controversial. Objective: Our purpose was to clarify if the epsilon 2 allele affects regional cortical thicknesses and volumes. Methods: Regional cortical thicknesses and volumes were measured with an automated pipeline in 109 subjects with mild cognitive impairment, 114 AD patients and 105 age-matched healthy controls. Results: In the mild cognitive impairment group, the epsilon 2 carriers had thicker regional cortices at the transverse temporal cortex and parahippocampal gyrus than the subjects with epsilon 3/epsilon 3, and a larger cerebral gray matter and smaller lateral ventricles than the epsilon 3/epsilon 3 and epsilon 4 carriers. In the AD group, the epsilon 2 carriers had significantly thicker entorhinal and transverse temporal cortices, a larger whole cerebral gray matter, and smaller lateral ventricles than the subjects with the epsilon 3/epsilon 3 genotype, and a significantly thicker entorhinal cortex and larger cerebral gray matter than epsilon 4 carriers. No APOE2 effect was found in the control group. Conclusion: The APOE epsilon 2 allele is associated with larger regional cortical thicknesses and volumes in mild cognitive impairment and AD. Copyright (C) 2010 S. Karger AG, Basel

U2 - 10.1159/000320136

DO - 10.1159/000320136

M3 - Article

VL - 30

SP - 229

EP - 237

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

SN - 1420-8008

IS - 3

ER -

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