Apple and blackcurrant polyphenol-rich drinks decrease postprandial glucose, insulin and incretin response to a high-carbohydrate meal in healthy men and women

Monica L Castro-Acosta, Stephanie G Stone, Jonathan E Mok, Rhia K Mhajan, Chi-Ieng Fu, Georgia N Lenihan-Geels, Christopher P Corpe, Wendy L Hall

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81 Citations (Scopus)
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Abstract

Postprandial glycemic responses to meals are inhibited by polyphenol-rich plant foods. Combinations of polyphenols may be particularly effective through complementary mechanisms. A randomized, controlled, double-blinded cross-over trial was conducted in healthy volunteers to test the hypothesis that apple and blackcurrant polyphenol-rich drinks would reduce postprandial blood glucose concentrations. Secondary outcomes included insulin and glucose-dependent insulinotropic polypeptide (GIP) secretion. Twenty men (mean age 26 y, SD 8) and 5 postmenopausal women (mean age 57 y, SD 3) consumed a placebo drink (CON) and 2 polyphenol-rich drinks containing fruit extracts: either 1200 mg apple polyphenols (AE), or 600 mg apple polyphenols+600 mg blackcurrant anthocyanins (AE + BE), in random order with a starch and sucrose meal. Incremental areas under the curve (iAUC) for plasma glucose concentrations were lower following AE + BE over 0–30 and 0–120 min compared with CON; mean differences (95% CI) -32 mmol/L·min (−41, −22, P<.0005) and−52 mmol/L.min (−94, −9, P<.05), respectively. AE significantly reduced iAUC 0–30 min (mean difference−26 mmol/L.min, −35, −18, P<.0005) compared with CON, but the difference over 120 min was not significant. Postprandial insulin, C-peptide and GIP concentrations were significantly reduced relative to CON. A dose response inhibition of glucose transport was demonstrated in Caco-2 cells, including total and GLUT-mediated transport, and SGLT1-mediated glucose transport was strongly inhibited at all doses in Xenopus oocytes, following 10 min incubation with 0.125–4 mg apple polyphenols/ml. In conclusion, ingestion of apple and blackcurrant polyphenols decreased postprandial glycemia, which may be partly related to inhibition of intestinal glucose transport.
Original languageEnglish
Pages (from-to)53-62
Number of pages10
JournalJOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume49
Early online date27 Jul 2017
DOIs
Publication statusPublished - Nov 2017

Keywords

  • randomized controlled trial
  • postprandial blood glucose
  • polyphenols
  • insulin
  • glucose-dependent insulinotropic polypeptide
  • apple

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