Application of artificial T cell receptor technology to cancer immunotherapy

    Research output: Contribution to journalLiterature reviewpeer-review

    Abstract

    Artificial T cell receptors provide a promising genetic approach to re-direct T lymphocyte specificity to tumour antigens. These molecules couple the MHC-independent recognition of a native antigen to the activation of T cell effector functions such as cytotoxicity. Recent developments in receptor design mean that T cells can also undergo extensive proliferation upon engagement with tumour cells bearing cognate antigen. Since these receptors can, in principle, be targeted to any cell surface-associated antigen, this technology may impact significantly upon adoptive cellular therapy of cancer
    Original languageEnglish
    Pages (from-to)89 - 91
    Number of pages3
    JournalCpd Bulletin Immunology & Allergy
    Volume2
    Issue number3
    Publication statusPublished - 2002

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