Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances

Hatem A.F.M. Hassan; Sandra S. Diebold; Lesley A. Smyth; Adam A. Walters; Giovanna Lombardi; Khuloud T. Al-Jamal

doi:10.1016/j.jconrel.2019.01.017

Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances

Hatem A.F.M. Hassan, Sandra S. Diebold, Lesley A. Smyth, Adam A. Walters, Giovanna Lombardi, Khuloud T. Al-Jamal^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

70 Citations (Scopus)

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Abstract

Tumour−specific, immuno−based therapeutic interventions can be considered as safe and effective approaches for cancer therapy. Exploitation of nano−vaccinology to intensify the cancer vaccine potency may overcome the need for administration of high vaccine doses or additional adjuvants and therefore could be a more efficient approach. Carbon nanotube (CNT) can be described as carbon sheet(s) rolled up into a cylinder that is nanometers wide and nanometers to micrometers long. Stemming from the observed capacities of CNTs to enter various types of cells via diversified mechanisms utilising energy−dependent and/or passive routes of cell uptake, the use of CNTs for the delivery of therapeutic agents has drawn increasing interests over the last decade. Here we review the previous studies that demonstrated the possible benefits of these cylindrical nano−vectors as cancer vaccine delivery systems as well as the obstacles their clinical application is facing.

Original language	English
Pages (from-to)	79-90
Number of pages	12
Journal	Journal of Controlled Release
Volume	297
DOIs	https://doi.org/10.1016/j.jconrel.2019.01.017
Publication status	Published - 10 Mar 2019

Keywords

Antigen presenting cells
Cancer immunotherapy
Carbon nanotube
Nanomedicine
Vaccine delivery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jconrel.2019.01.017

Hassan et al JCR 2019Accepted author manuscript, 765 KBLicence: CC BY-NC-ND

Cite this

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title = "Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances",

abstract = "Tumour−specific, immuno−based therapeutic interventions can be considered as safe and effective approaches for cancer therapy. Exploitation of nano−vaccinology to intensify the cancer vaccine potency may overcome the need for administration of high vaccine doses or additional adjuvants and therefore could be a more efficient approach. Carbon nanotube (CNT) can be described as carbon sheet(s) rolled up into a cylinder that is nanometers wide and nanometers to micrometers long. Stemming from the observed capacities of CNTs to enter various types of cells via diversified mechanisms utilising energy−dependent and/or passive routes of cell uptake, the use of CNTs for the delivery of therapeutic agents has drawn increasing interests over the last decade. Here we review the previous studies that demonstrated the possible benefits of these cylindrical nano−vectors as cancer vaccine delivery systems as well as the obstacles their clinical application is facing.",

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T2 - Achievements, challenges and chances

AU - Hassan, Hatem A.F.M.

AU - Diebold, Sandra S.

AU - Smyth, Lesley A.

AU - Walters, Adam A.

AU - Lombardi, Giovanna

AU - Al-Jamal, Khuloud T.

PY - 2019/3/10

Y1 - 2019/3/10

N2 - Tumour−specific, immuno−based therapeutic interventions can be considered as safe and effective approaches for cancer therapy. Exploitation of nano−vaccinology to intensify the cancer vaccine potency may overcome the need for administration of high vaccine doses or additional adjuvants and therefore could be a more efficient approach. Carbon nanotube (CNT) can be described as carbon sheet(s) rolled up into a cylinder that is nanometers wide and nanometers to micrometers long. Stemming from the observed capacities of CNTs to enter various types of cells via diversified mechanisms utilising energy−dependent and/or passive routes of cell uptake, the use of CNTs for the delivery of therapeutic agents has drawn increasing interests over the last decade. Here we review the previous studies that demonstrated the possible benefits of these cylindrical nano−vectors as cancer vaccine delivery systems as well as the obstacles their clinical application is facing.

AB - Tumour−specific, immuno−based therapeutic interventions can be considered as safe and effective approaches for cancer therapy. Exploitation of nano−vaccinology to intensify the cancer vaccine potency may overcome the need for administration of high vaccine doses or additional adjuvants and therefore could be a more efficient approach. Carbon nanotube (CNT) can be described as carbon sheet(s) rolled up into a cylinder that is nanometers wide and nanometers to micrometers long. Stemming from the observed capacities of CNTs to enter various types of cells via diversified mechanisms utilising energy−dependent and/or passive routes of cell uptake, the use of CNTs for the delivery of therapeutic agents has drawn increasing interests over the last decade. Here we review the previous studies that demonstrated the possible benefits of these cylindrical nano−vectors as cancer vaccine delivery systems as well as the obstacles their clinical application is facing.

KW - Antigen presenting cells

KW - Cancer immunotherapy

KW - Carbon nanotube

KW - Nanomedicine

KW - Vaccine delivery

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SP - 79

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JF - Journal of Controlled Release

ER -

Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances

Abstract

Keywords

UN SDGs

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