TY - CHAP
T1 - Application of diffuse optical reflectance to measure myocardial wall thickness and presence of infarct scar
T2 - 8th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2015
AU - Tang, Yee Chia
AU - Bishop, Martin J.
PY - 2015/6/21
Y1 - 2015/6/21
N2 - Catheter ablation in patients suffering from chronic arrhythmias often requires detailed knowledge of the specific myocardial anatomy underlying the catheter tip to guide the delivery of the ablating RF energy. Such information is often lacking in a clinical procedure. In this study, we present a proof-of-concept computational investigation into the potential for using an optical strategy, based-on diffuse optical reflectance, to provide quantitative anatomical measures of underlying myocardial wall thickness and presence of scar. In detailed Monte Carlo simulations of light scattering, significant changes in peak height and FWHM of radial profiles of diffusely reflected light were seen with both changes in tissue thickness and presence of underlying scar. Such changes were seen to occur to different degrees for different wavelengths of light. In conclusion, our findings suggest that examining the ratio of these changes between different wavelengths may provide the potential basis for an optical-catheter to map underlying cardiac anatomy and guide ablation in the clinic.
AB - Catheter ablation in patients suffering from chronic arrhythmias often requires detailed knowledge of the specific myocardial anatomy underlying the catheter tip to guide the delivery of the ablating RF energy. Such information is often lacking in a clinical procedure. In this study, we present a proof-of-concept computational investigation into the potential for using an optical strategy, based-on diffuse optical reflectance, to provide quantitative anatomical measures of underlying myocardial wall thickness and presence of scar. In detailed Monte Carlo simulations of light scattering, significant changes in peak height and FWHM of radial profiles of diffusely reflected light were seen with both changes in tissue thickness and presence of underlying scar. Such changes were seen to occur to different degrees for different wavelengths of light. In conclusion, our findings suggest that examining the ratio of these changes between different wavelengths may provide the potential basis for an optical-catheter to map underlying cardiac anatomy and guide ablation in the clinic.
UR - http://www.scopus.com/inward/record.url?scp=84949942837&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-20309-6_29
DO - 10.1007/978-3-319-20309-6_29
M3 - Chapter
AN - SCOPUS:84949942837
SN - 9783319203089
SN - 9783319203089
VL - 9126
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 248
EP - 255
BT - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
PB - Springer-Verlag Berlin Heidelberg
Y2 - 25 June 2015 through 27 June 2015
ER -