TY - JOUR
T1 - Applications of genome-scale metabolic models in biotechnology and systems medicine
AU - Zhang, Cheng
AU - Hua, Qiang
N1 - Publisher Copyright:
© 2016 Zhang and Hua.
PY - 2016/1/7
Y1 - 2016/1/7
N2 - Genome-scale metabolic models (GEMs) have become a popular tool for systems biology, and they have been used in many fields such as industrial biotechnology and systems medicine. Since more and more studies are being conducted using GEMs, they have recently received considerable attention. In this review, we introduce the basic concept of GEMs and provide an overview of their applications in biotechnology, systems medicine, and some other fields. In addition, we describe the general principle of the applications and analyses built on GEMs. The purpose of this review is to introduce the application of GEMs in biological analysis and to promote its wider use by biologists.
AB - Genome-scale metabolic models (GEMs) have become a popular tool for systems biology, and they have been used in many fields such as industrial biotechnology and systems medicine. Since more and more studies are being conducted using GEMs, they have recently received considerable attention. In this review, we introduce the basic concept of GEMs and provide an overview of their applications in biotechnology, systems medicine, and some other fields. In addition, we describe the general principle of the applications and analyses built on GEMs. The purpose of this review is to introduce the application of GEMs in biological analysis and to promote its wider use by biologists.
KW - Genome-scale metabolic models
KW - In silico metabolic engineering
KW - Metabolic capability analysis
KW - Systems biology
KW - Systems medicine
UR - http://www.scopus.com/inward/record.url?scp=84962176145&partnerID=8YFLogxK
U2 - 10.3389/fphys.2015.00413
DO - 10.3389/fphys.2015.00413
M3 - Short survey
AN - SCOPUS:84962176145
SN - 1664-042X
VL - 6
JO - Frontiers in Physiology
JF - Frontiers in Physiology
IS - JAN
M1 - 413
ER -