Appreciating force and shape—the rise of mechanotransduction in cell biology

Thomas Iskratsch; Haguy Wolfenson; Michael P Sheetz

doi:10.1038/nrm3903

Appreciating force and shape—the rise of mechanotransduction in cell biology

Thomas Iskratsch, Haguy Wolfenson, Michael P Sheetz

Research output: Contribution to journal › Article › peer-review

625 Citations (Scopus)

Abstract

Although the shapes of organisms are encoded in their genome, the developmental processes that lead to the final form of vertebrates involve a constant feedback between dynamic mechanical forces, and cell growth and motility. Mechanobiology has emerged as a discipline dedicated to the study of the effects of mechanical forces and geometry on cell growth and motility—for example, during cell-matrix adhesion development—through the signalling process of mechanotransduction.

Original language	English
Pages (from-to)	825-833
Number of pages	9
Journal	Nature reviews. Molecular cell biology
Volume	15
Issue number	12
DOIs	https://doi.org/10.1038/nrm3903
Publication status	Published - Dec 2014

Keywords

Animals
Biomechanical Phenomena
Cell Biology
Extracellular Matrix
History, 20th Century
History, 21st Century
Mechanotransduction, Cellular

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10.1038/nrm3903

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abstract = "Although the shapes of organisms are encoded in their genome, the developmental processes that lead to the final form of vertebrates involve a constant feedback between dynamic mechanical forces, and cell growth and motility. Mechanobiology has emerged as a discipline dedicated to the study of the effects of mechanical forces and geometry on cell growth and motility—for example, during cell-matrix adhesion development—through the signalling process of mechanotransduction.",

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KW - Animals

KW - Biomechanical Phenomena

KW - Cell Biology

KW - Extracellular Matrix

KW - History, 20th Century

KW - History, 21st Century

KW - Mechanotransduction, Cellular

U2 - 10.1038/nrm3903

DO - 10.1038/nrm3903

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JO - Nature reviews. Molecular cell biology

JF - Nature reviews. Molecular cell biology

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Appreciating force and shape—the rise of mechanotransduction in cell biology

Abstract

Keywords

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