Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase

TY - JOUR

T1 - Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase

AU - Jadoon, Ayesha

AU - Cunningham, Philip

AU - McDermott, Lindsay

PY - 2014/6

Y1 - 2014/6

N2 - Arachidonic acid (ARA) metabolites maintain pregnancy and control parturition. We generated a network of 77 proteins involved in placental ARA metabolism to identify novel proteins in this pathway. We identified a long pathway within this network which showed that secretory and cytosolic phospholipase A2 proteins act in concert. The functions of all network proteins expressed in the placental decidua were determined by database searches. Thus ARA metabolism was linked to carbohydrate metabolism. One protein, transmembrane protein 62 (TMEM62), expressed in decidua was previously uncharacterized, and was identified as a putative lipoxygenase. TMEM62 may play a role in pregnancy and/or parturition.

AB - Arachidonic acid (ARA) metabolites maintain pregnancy and control parturition. We generated a network of 77 proteins involved in placental ARA metabolism to identify novel proteins in this pathway. We identified a long pathway within this network which showed that secretory and cytosolic phospholipase A2 proteins act in concert. The functions of all network proteins expressed in the placental decidua were determined by database searches. Thus ARA metabolism was linked to carbohydrate metabolism. One protein, transmembrane protein 62 (TMEM62), expressed in decidua was previously uncharacterized, and was identified as a putative lipoxygenase. TMEM62 may play a role in pregnancy and/or parturition.

U2 - 10.1016/j.placenta.2014.03.024

DO - 10.1016/j.placenta.2014.03.024

M3 - Article

SN - 0143-4004

VL - 35

SP - 422

EP - 424

JO - Placenta

JF - Placenta

IS - 6

ER -