Are Lifestyle Therapies Effective for NAFLD Treatment?

Nermeen N. El-Agroudy, Anica Kurzbach, Roman N. Rodionov, John O'Sullivan, Michael Roden, Andreas L. Birkenfeld*, Dominik H. Pesta

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

93 Citations (Scopus)

Abstract

Nonalcoholic fatty liver disease (NAFLD) is becoming the most common liver disorder worldwide. Specifically, nonalcoholic steatohepatitis (NASH) and fibrosis pose an enormous burden for patients and health-care systems. In the absence of approved pharmacological therapies, effective lifestyle interventions for NAFLD, such as dietary strategies and exercise training, are currently the therapeutic strategies of choice. This review covers the influence of macronutrient quality and quantity (i.e., low-carbohydrate and high-protein diets), for successful reduction of intrahepatocellular lipids (IHL). Moreover, we discuss the effectiveness of different modalities of physical exercising with and without weight loss. These lifestyle modifications not only provide strategies to reduce IHL but may also hold a still underestimated potential to induce improvement and/or even remission of NAFLD.

Original languageEnglish
Pages (from-to)701-709
Number of pages9
JournalTRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume30
Issue number10
DOIs
Publication statusPublished - 1 Oct 2019

Keywords

  • exercise
  • lifestyle modification
  • NAFLD
  • nutrition
  • physical activity
  • weight loss

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