Are Parkinson's disease with dementia and dementia with Lewy bodies the same entity?

TY - JOUR

T1 - Are Parkinson's disease with dementia and dementia with Lewy bodies the same entity?

AU - Aarsland, D

AU - Ballard, C G

AU - Halliday, G

PY - 2004/9

Y1 - 2004/9

N2 - The diagnosis of Parkinson's disease with dementia (PDD) or dementia with Lewy bodies (DLB) is based on an arbitrary distinction between the time of onset of motor and cognitive symptoms. These syndromes share many neurobiological similarities, but there are also differences. Deposition of beta-amyloid protein is more marked and more closely related to cognitive impairment in DLB than PDD, possibly contributing to dementia at onset. The relatively more severe executive impairment in DLB than PDD may relate to the loss of frontohippocampal projections in DLB. Visual hallucinations and delusions associate with more abundant Lewy body pathology in temporal cortex in DLB. The differential involvement of pathology in the striatum may account for the differences in parkinsonism. Longitudinal studies with neuropathological and neurochemical evaluations will be essential to enable more robust comparisons and determine pathological substrates contributing to the differences in cognitive, motor, and psychiatric symptoms.

AB - The diagnosis of Parkinson's disease with dementia (PDD) or dementia with Lewy bodies (DLB) is based on an arbitrary distinction between the time of onset of motor and cognitive symptoms. These syndromes share many neurobiological similarities, but there are also differences. Deposition of beta-amyloid protein is more marked and more closely related to cognitive impairment in DLB than PDD, possibly contributing to dementia at onset. The relatively more severe executive impairment in DLB than PDD may relate to the loss of frontohippocampal projections in DLB. Visual hallucinations and delusions associate with more abundant Lewy body pathology in temporal cortex in DLB. The differential involvement of pathology in the striatum may account for the differences in parkinsonism. Longitudinal studies with neuropathological and neurochemical evaluations will be essential to enable more robust comparisons and determine pathological substrates contributing to the differences in cognitive, motor, and psychiatric symptoms.

UR - http://www.scopus.com/inward/record.url?scp=4344643801&partnerID=8YFLogxK

U2 - 10.1177/0891988704267470

DO - 10.1177/0891988704267470

M3 - Article

VL - 17

SP - 137

EP - 145

JO - Journal of Geriatric Psychiatry and Neurology

JF - Journal of Geriatric Psychiatry and Neurology

IS - 3

ER -