Are snoRNAs and snoRNA host genes new players in cancer?

TY - JOUR

T1 - Are snoRNAs and snoRNA host genes new players in cancer?

AU - Williams, Gwyn T.

AU - Farzaneh, Farzin

PY - 2012/2

Y1 - 2012/2

N2 - Small nucleolar RNAs (snoRNAs) have long been considered important but unglamorous elements in the production of the protein synthesis machinery of the cell. Recently, however, several independent lines of evidence have indicated that these non-coding RNAs might have crucial roles in controlling cell behaviour, and snoRNA dysfunction could consequently contribute to oncogenesis in previously unsuspected ways.

AB - Small nucleolar RNAs (snoRNAs) have long been considered important but unglamorous elements in the production of the protein synthesis machinery of the cell. Recently, however, several independent lines of evidence have indicated that these non-coding RNAs might have crucial roles in controlling cell behaviour, and snoRNA dysfunction could consequently contribute to oncogenesis in previously unsuspected ways.

KW - Animals

KW - Humans

KW - Neoplasms

KW - RNA Processing, Post-Transcriptional

KW - RNA, Small Nucleolar

U2 - 10.1038/nrc3195

DO - 10.1038/nrc3195

M3 - Article

C2 - 22257949

VL - 12

SP - 84

EP - 88

JO - NATURE REVIEWS CANCER

JF - NATURE REVIEWS CANCER

IS - 2

M1 - N/A

ER -