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Are the risks of treatment to cure a child with severe sickle cell disease too high?

Research output: Contribution to journalComment/debate

Mariane de Montalembert, Valentine Brousse, Subarna Chakravorty, Antonio Pagliuca, John Porter, Paul Telfer, Ajay Vora, David C Rees

Original languageEnglish
Article numberj5250
JournalBMJ (Clinical research ed.)
Volume359
Early online date23 Nov 2017
DOIs
Publication statusPublished - 2017

King's Authors

Abstract

Key messages
Curative treatment for sickle cell disease is potentially available to all patients using haematopoietic stem cell transplantation from alternative donors, but the risks of these procedures are very high
We don’t know when these high risk transplants should be offered to children or how parents should be counselled to give appropriate consent
In high income countries, non-transplant treatments are being developed for sickle cell disease that are likely to improve prognosis
We need to develop safer transplants and to explore the ethics of offering high risk procedures to children with sickle cell disease and other chronic conditions

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