Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet

Jordi Alastruey, Peter H Charlton, Vasiliki Bikia, Birute Paliakaitė, Bernhard Hametner, Rosa Maria Bruno, Marijn P Mulder, Samuel Vennin, Senol Piskin, Ashraf W Khir, Andrea Guala, Christopher C Mayer, Jonathan Mynard, Alun D Hughes, Patrick Segers, Berend E Westerhof

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)
78 Downloads (Pure)


Arterial pulse waves (PWs) such as blood pressure and photoplethysmogram (PPG) signals contain a wealth of information on the cardiovascular (CV) system that can be exploited to assess vascular age and identify individuals at elevated CV risk. We review the possibilities, limitations, complementarity, and differences of reduced-order, biophysical models of arterial PW propagation, as well as theoretical and empirical methods for analyzing PW signals and extracting clinically relevant information for vascular age assessment. We provide detailed mathematical derivations of these models and theoretical methods, showing how they are related to each other. Finally, we outline directions for future research to realize the potential of modeling and analysis of PW signals for accurate assessment of vascular age in both the clinic and in daily life.

Original languageEnglish
Pages (from-to)H1-H29
JournalAmerican journal of physiology. Heart and circulatory physiology
Issue number1
Early online date31 Mar 2023
Publication statusPublished - 1 Jul 2023


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