TY - JOUR
T1 - Artificial intelligence for biomarker discovery in Alzheimer’s disease and dementia
AU - Winchester, Laura M.
AU - Harshfield, Eric
AU - Shi, Liu
AU - Badhwar, AmanPreet
AU - Al Khleifat, Ahmad
AU - Clarke, Natasha
AU - Dehsarvi, Amir
AU - Lengyel, Imre
AU - Lourida, Ilianna
AU - Madan, Christopher R.
AU - Marzi, Sarah
AU - Proitsi, Petroula
AU - Rajamani, Anto Praveen Rajkumar
AU - Rittman, Timothy
AU - Silajdzic, Edina
AU - Tamburin, Stefano
AU - Ranson, Janice M.
AU - Llewellyn, David J.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - With the increase in large multimodal cohorts and high-throughput technologies, the potential for discovering novel biomarkers is no longer limited by data set size. Artificial intelligence (AI) and machine learning approaches have been developed to detect novel biomarkers and interactions in complex data sets. We discuss exemplar uses and evalu- ate current applications and limitations of AI to discover novel biomarkers. Remaining challenges include a lack of diversity in the data sets available, the sheer complex- ity of investigating interactions, the invasiveness and cost of some biomarkers, and poor reporting in some studies. Overcoming these challenges will involve collecting
AB - With the increase in large multimodal cohorts and high-throughput technologies, the potential for discovering novel biomarkers is no longer limited by data set size. Artificial intelligence (AI) and machine learning approaches have been developed to detect novel biomarkers and interactions in complex data sets. We discuss exemplar uses and evalu- ate current applications and limitations of AI to discover novel biomarkers. Remaining challenges include a lack of diversity in the data sets available, the sheer complex- ity of investigating interactions, the invasiveness and cost of some biomarkers, and poor reporting in some studies. Overcoming these challenges will involve collecting
M3 - Review article
JO - Alzheimer's Dementia: The Journal of the Alzheimer's Association
JF - Alzheimer's Dementia: The Journal of the Alzheimer's Association
ER -