Aspirin modifies nitric oxide synthase activity in platelets: effects of acute versus chronic aspirin treatment

TY - JOUR

T1 - Aspirin modifies nitric oxide synthase activity in platelets: effects of acute versus chronic aspirin treatment

AU - O'Kane, P D

AU - Queen, L R

AU - Ji, Y

AU - Reebye, V

AU - Stratton, P

AU - Jackson, G

AU - Ferro, A

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Objective: We examined the effects of aspirin on basal and beta-adrenoceptor (beta-AR)-mediated nitric oxide synthase (NOS) activity in normal platelets. Methods: NOS activity was determined from the conversion of L-[H-3]arginine to L-[H-3]citrulline, both basally and following beta-AR stimulation, in platelets from healthy human subjects following both short- and long-term aspirin administration. Results: Basal L-[H-3]citrulline increased following asprin 800 mg administered intravenously in vivo, from 0.31+/-0.12 to 0.76+/-0.14 pmol/10(8) platelets (P

AB - Objective: We examined the effects of aspirin on basal and beta-adrenoceptor (beta-AR)-mediated nitric oxide synthase (NOS) activity in normal platelets. Methods: NOS activity was determined from the conversion of L-[H-3]arginine to L-[H-3]citrulline, both basally and following beta-AR stimulation, in platelets from healthy human subjects following both short- and long-term aspirin administration. Results: Basal L-[H-3]citrulline increased following asprin 800 mg administered intravenously in vivo, from 0.31+/-0.12 to 0.76+/-0.14 pmol/10(8) platelets (P

UR - http://www.scopus.com/inward/record.url?scp=0038094528&partnerID=8YFLogxK

U2 - 10.1016/S0008-6363(03)00323-7

DO - 10.1016/S0008-6363(03)00323-7

M3 - Article

SN - 1755-3245

VL - 59

SP - 152

EP - 159

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 1

ER -