King's College London

Research portal

Assessing cognition and daily function in early dementia using the cognitive-functional composite: Findings from the Catch-Cog study cohort

Research output: Contribution to journalArticlepeer-review

Standard

Assessing cognition and daily function in early dementia using the cognitive-functional composite : Findings from the Catch-Cog study cohort. / Jutten, Roos J.; Harrison, John E.; Lee Meeuw Kjoe, Philippe R. et al.

In: Alzheimer's Research and Therapy, Vol. 11, No. 1, 45, 15.05.2019.

Research output: Contribution to journalArticlepeer-review

Harvard

Jutten, RJ, Harrison, JE, Lee Meeuw Kjoe, PR, Ingala, S, Vreeswijk, R, Van Deelen, RAJ, De Jong, FJ, Opmeer, EM, Aleman, A, Ritchie, CW, Scheltens, P & Sikkes, SAM 2019, 'Assessing cognition and daily function in early dementia using the cognitive-functional composite: Findings from the Catch-Cog study cohort', Alzheimer's Research and Therapy, vol. 11, no. 1, 45. https://doi.org/10.1186/s13195-019-0500-5

APA

Jutten, R. J., Harrison, J. E., Lee Meeuw Kjoe, P. R., Ingala, S., Vreeswijk, R., Van Deelen, R. A. J., De Jong, F. J., Opmeer, E. M., Aleman, A., Ritchie, C. W., Scheltens, P., & Sikkes, S. A. M. (2019). Assessing cognition and daily function in early dementia using the cognitive-functional composite: Findings from the Catch-Cog study cohort. Alzheimer's Research and Therapy, 11(1), [45]. https://doi.org/10.1186/s13195-019-0500-5

Vancouver

Jutten RJ, Harrison JE, Lee Meeuw Kjoe PR, Ingala S, Vreeswijk R, Van Deelen RAJ et al. Assessing cognition and daily function in early dementia using the cognitive-functional composite: Findings from the Catch-Cog study cohort. Alzheimer's Research and Therapy. 2019 May 15;11(1). 45. https://doi.org/10.1186/s13195-019-0500-5

Author

Jutten, Roos J. ; Harrison, John E. ; Lee Meeuw Kjoe, Philippe R. et al. / Assessing cognition and daily function in early dementia using the cognitive-functional composite : Findings from the Catch-Cog study cohort. In: Alzheimer's Research and Therapy. 2019 ; Vol. 11, No. 1.

Bibtex Download

@article{4d34c6675cec431284825d0c265f74a2,
title = "Assessing cognition and daily function in early dementia using the cognitive-functional composite: Findings from the Catch-Cog study cohort",
abstract = "Background: The cognitive-functional composite (CFC) was designed to improve the measurement of clinically relevant changes in predementia and early dementia stages. We have previously demonstrated its good test-retest reliability and feasibility of use. The current study aimed to evaluate several quality aspects of the CFC, including construct validity, clinical relevance, and suitability for the target population. Methods: Baseline data of the Capturing Changes in Cognition study was used: an international, prospective cohort study including participants with subjective cognitive decline (SCD), mild cognitive impairment (MCI), Alzheimer's disease (AD) dementia, and dementia with Lewy bodies (DLB). The CFC comprises seven existing cognitive tests focusing on memory and executive functions (EF) and the informant-based Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q). Construct validity and clinical relevance were assessed by (1) confirmatory factor analyses (CFA) using all CFC subtests and (2) linear regression analyses relating the CFC score (independent) to reference measures of disease severity (dependent), correcting for age, sex, and education. To assess the suitability for the target population, we compared score distributions of the CFC to those of traditional tests (Alzheimer's Disease Assessment Scale-Cognitive subscale, Alzheimer's Disease Cooperative Study-Activities of Daily Living scale, and Clinical Dementia Rating scale). Results: A total of 184 participants were included (age 71.8 ± 8.4; 42% female; n = 14 SCD, n = 80 MCI, n = 78 AD, and n = 12 DLB). CFA showed that the hypothesized three-factor model (memory, EF, and IADL) had adequate fit (CFI =.931, RMSEA =.091, SRMR =.06). Moreover, worse CFC performance was associated with more cognitive decline as reported by the informant (β =.61, p <.001), poorer quality of life (β =.51, p <.001), higher caregiver burden (β = -.51, p <.001), more apathy (β = -.36, p <.001), and less cortical volume (β =.34, p =.02). Whilst correlations between the CFC and traditional measures were moderate to strong (ranging from -.65 to.83, all p <.001), histograms showed floor and ceiling effects for the traditional tests as compared to the CFC. Conclusions: Our findings illustrate that the CFC has good construct validity, captures clinically relevant aspects of disease severity, and shows no range restrictions in scoring. It therefore provides a more useful outcome measure than traditional tests to evaluate cognition and function in MCI and mild AD.",
keywords = "Alzheimer's disease, Cognition, Composite, Construct validation, Daily function, Dementia, Instrumental activities of daily living, Mild cognitive impairment, Outcome measures",
author = "Jutten, {Roos J.} and Harrison, {John E.} and {Lee Meeuw Kjoe}, {Philippe R.} and Silvia Ingala and R. Vreeswijk and {Van Deelen}, {R. A.J.} and {De Jong}, {Frank Jan} and Opmeer, {Esther M.} and Andr{\'e} Aleman and Ritchie, {Craig W.} and Philip Scheltens and Sikkes, {Sietske A.M.}",
year = "2019",
month = may,
day = "15",
doi = "10.1186/s13195-019-0500-5",
language = "English",
volume = "11",
journal = "Alzheimer's research & therapy",
issn = "1758-9193",
publisher = "BioMed Central",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Assessing cognition and daily function in early dementia using the cognitive-functional composite

T2 - Findings from the Catch-Cog study cohort

AU - Jutten, Roos J.

AU - Harrison, John E.

AU - Lee Meeuw Kjoe, Philippe R.

AU - Ingala, Silvia

AU - Vreeswijk, R.

AU - Van Deelen, R. A.J.

AU - De Jong, Frank Jan

AU - Opmeer, Esther M.

AU - Aleman, André

AU - Ritchie, Craig W.

AU - Scheltens, Philip

AU - Sikkes, Sietske A.M.

PY - 2019/5/15

Y1 - 2019/5/15

N2 - Background: The cognitive-functional composite (CFC) was designed to improve the measurement of clinically relevant changes in predementia and early dementia stages. We have previously demonstrated its good test-retest reliability and feasibility of use. The current study aimed to evaluate several quality aspects of the CFC, including construct validity, clinical relevance, and suitability for the target population. Methods: Baseline data of the Capturing Changes in Cognition study was used: an international, prospective cohort study including participants with subjective cognitive decline (SCD), mild cognitive impairment (MCI), Alzheimer's disease (AD) dementia, and dementia with Lewy bodies (DLB). The CFC comprises seven existing cognitive tests focusing on memory and executive functions (EF) and the informant-based Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q). Construct validity and clinical relevance were assessed by (1) confirmatory factor analyses (CFA) using all CFC subtests and (2) linear regression analyses relating the CFC score (independent) to reference measures of disease severity (dependent), correcting for age, sex, and education. To assess the suitability for the target population, we compared score distributions of the CFC to those of traditional tests (Alzheimer's Disease Assessment Scale-Cognitive subscale, Alzheimer's Disease Cooperative Study-Activities of Daily Living scale, and Clinical Dementia Rating scale). Results: A total of 184 participants were included (age 71.8 ± 8.4; 42% female; n = 14 SCD, n = 80 MCI, n = 78 AD, and n = 12 DLB). CFA showed that the hypothesized three-factor model (memory, EF, and IADL) had adequate fit (CFI =.931, RMSEA =.091, SRMR =.06). Moreover, worse CFC performance was associated with more cognitive decline as reported by the informant (β =.61, p <.001), poorer quality of life (β =.51, p <.001), higher caregiver burden (β = -.51, p <.001), more apathy (β = -.36, p <.001), and less cortical volume (β =.34, p =.02). Whilst correlations between the CFC and traditional measures were moderate to strong (ranging from -.65 to.83, all p <.001), histograms showed floor and ceiling effects for the traditional tests as compared to the CFC. Conclusions: Our findings illustrate that the CFC has good construct validity, captures clinically relevant aspects of disease severity, and shows no range restrictions in scoring. It therefore provides a more useful outcome measure than traditional tests to evaluate cognition and function in MCI and mild AD.

AB - Background: The cognitive-functional composite (CFC) was designed to improve the measurement of clinically relevant changes in predementia and early dementia stages. We have previously demonstrated its good test-retest reliability and feasibility of use. The current study aimed to evaluate several quality aspects of the CFC, including construct validity, clinical relevance, and suitability for the target population. Methods: Baseline data of the Capturing Changes in Cognition study was used: an international, prospective cohort study including participants with subjective cognitive decline (SCD), mild cognitive impairment (MCI), Alzheimer's disease (AD) dementia, and dementia with Lewy bodies (DLB). The CFC comprises seven existing cognitive tests focusing on memory and executive functions (EF) and the informant-based Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q). Construct validity and clinical relevance were assessed by (1) confirmatory factor analyses (CFA) using all CFC subtests and (2) linear regression analyses relating the CFC score (independent) to reference measures of disease severity (dependent), correcting for age, sex, and education. To assess the suitability for the target population, we compared score distributions of the CFC to those of traditional tests (Alzheimer's Disease Assessment Scale-Cognitive subscale, Alzheimer's Disease Cooperative Study-Activities of Daily Living scale, and Clinical Dementia Rating scale). Results: A total of 184 participants were included (age 71.8 ± 8.4; 42% female; n = 14 SCD, n = 80 MCI, n = 78 AD, and n = 12 DLB). CFA showed that the hypothesized three-factor model (memory, EF, and IADL) had adequate fit (CFI =.931, RMSEA =.091, SRMR =.06). Moreover, worse CFC performance was associated with more cognitive decline as reported by the informant (β =.61, p <.001), poorer quality of life (β =.51, p <.001), higher caregiver burden (β = -.51, p <.001), more apathy (β = -.36, p <.001), and less cortical volume (β =.34, p =.02). Whilst correlations between the CFC and traditional measures were moderate to strong (ranging from -.65 to.83, all p <.001), histograms showed floor and ceiling effects for the traditional tests as compared to the CFC. Conclusions: Our findings illustrate that the CFC has good construct validity, captures clinically relevant aspects of disease severity, and shows no range restrictions in scoring. It therefore provides a more useful outcome measure than traditional tests to evaluate cognition and function in MCI and mild AD.

KW - Alzheimer's disease

KW - Cognition

KW - Composite

KW - Construct validation

KW - Daily function

KW - Dementia

KW - Instrumental activities of daily living

KW - Mild cognitive impairment

KW - Outcome measures

UR - http://www.scopus.com/inward/record.url?scp=85066055585&partnerID=8YFLogxK

U2 - 10.1186/s13195-019-0500-5

DO - 10.1186/s13195-019-0500-5

M3 - Article

AN - SCOPUS:85066055585

VL - 11

JO - Alzheimer's research & therapy

JF - Alzheimer's research & therapy

SN - 1758-9193

IS - 1

M1 - 45

ER -

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454