Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study

Aida Sem Ic-Jusufagic; Danielle Belgrave; Andrew Pickles; Aurica G. Telcian; Eteri Bakhsoliani; Annemarie Sykes; Angela Simpson; Sebastian L. Johnston; Adnan Custovic

doi:10.1016/S2213-2600(14)70096-7

Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study

Aida Sem Ic-Jusufagic, Danielle Belgrave, Andrew Pickles, Aurica G. Telcian, Eteri Bakhsoliani, Annemarie Sykes, Angela Simpson, Sebastian L. Johnston, Adnan Custovic^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

Background The relationship between early-life antibiotic use and the development of wheeze and asthma has been reported in several studies but might arise as a consequence of bias rather than causal relationship. We investigated the association between antibiotic prescription and subsequent development of atopy, wheeze, and asthma exacerbations, and the relation of early life antibiotic prescription with anti-infective immunity and genetic variants on asthma susceptibility locus 17q21.

Methods Children in a population-based birth cohort were followed from birth to age 11 years. Information on antibiotic prescription, wheeze, and asthma exacerbations was extracted from medical records, and the effect of antibiotic prescription assessed with longitudinal analyses. We assessed immune responses of peripheral blood mononuclear cells, taken at age 11 years, to viruses (rhinovirus and respiratory syncytial virus; RSV) and bacteria (Haemophilus influenzae and Streptococcus pneumoniae) in children who either received at least one or no antibiotic prescriptions in infancy. Finally, we assessed the association of 17q21 polymorphisms with antibiotic prescription.

Findings Of 984 families who gave consent, we extracted data for 916 children. We noted significantly higher risk of physician-confirmed wheezing after antibiotic prescription (hazard ratio [HR] 1.71,95% CI 1.32-2.23; p

Interpretation The association between antibiotics and asthma might arise through a complex confounding by indication. Hidden factors that may increase the likelihood of both early life antibiotic prescription and later asthma are an increased susceptibility to viral infections consequent upon impaired antiviral immunity and genetic variants on 17q21.

Original language	English
Pages (from-to)	621-630
Number of pages	10
Journal	The lancet. Respiratory medicine
Volume	2
Issue number	8
DOIs	https://doi.org/10.1016/S2213-2600(14)70096-7
Publication status	Published - Aug 2014

Keywords

RESPIRATORY-INFECTIONS
SUBSEQUENT DEVELOPMENT
CHILDHOOD ASTHMA
CHILDREN
RISK
EXPOSURE
COMPLICATIONS
PHENOTYPES
PREGNANCY
ALLERGY

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10.1016/S2213-2600(14)70096-7

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Ic-Jusufagic, A. S., Belgrave, D., Pickles, A., Telcian, A. G., Bakhsoliani, E., Sykes, A., Simpson, A., Johnston, S. L., & Custovic, A. (2014). Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study. The lancet. Respiratory medicine, 2(8), 621-630. https://doi.org/10.1016/S2213-2600(14)70096-7

@article{4a53000cfbbc4b9185b4e35e39eac050,

title = "Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study",

abstract = "Background The relationship between early-life antibiotic use and the development of wheeze and asthma has been reported in several studies but might arise as a consequence of bias rather than causal relationship. We investigated the association between antibiotic prescription and subsequent development of atopy, wheeze, and asthma exacerbations, and the relation of early life antibiotic prescription with anti-infective immunity and genetic variants on asthma susceptibility locus 17q21.Methods Children in a population-based birth cohort were followed from birth to age 11 years. Information on antibiotic prescription, wheeze, and asthma exacerbations was extracted from medical records, and the effect of antibiotic prescription assessed with longitudinal analyses. We assessed immune responses of peripheral blood mononuclear cells, taken at age 11 years, to viruses (rhinovirus and respiratory syncytial virus; RSV) and bacteria (Haemophilus influenzae and Streptococcus pneumoniae) in children who either received at least one or no antibiotic prescriptions in infancy. Finally, we assessed the association of 17q21 polymorphisms with antibiotic prescription.Findings Of 984 families who gave consent, we extracted data for 916 children. We noted significantly higher risk of physician-confirmed wheezing after antibiotic prescription (hazard ratio [HR] 1.71,95% CI 1.32-2.23; pInterpretation The association between antibiotics and asthma might arise through a complex confounding by indication. Hidden factors that may increase the likelihood of both early life antibiotic prescription and later asthma are an increased susceptibility to viral infections consequent upon impaired antiviral immunity and genetic variants on 17q21.",

keywords = "RESPIRATORY-INFECTIONS, SUBSEQUENT DEVELOPMENT, CHILDHOOD ASTHMA, CHILDREN, RISK, EXPOSURE, COMPLICATIONS, PHENOTYPES, PREGNANCY, ALLERGY",

author = "Ic-Jusufagic, {Aida Sem} and Danielle Belgrave and Andrew Pickles and Telcian, {Aurica G.} and Eteri Bakhsoliani and Annemarie Sykes and Angela Simpson and Johnston, {Sebastian L.} and Adnan Custovic",

year = "2014",

month = aug,

doi = "10.1016/S2213-2600(14)70096-7",

language = "English",

volume = "2",

pages = "621--630",

journal = "The lancet. Respiratory medicine",

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number = "8",

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Ic-Jusufagic, AS, Belgrave, D, Pickles, A, Telcian, AG, Bakhsoliani, E, Sykes, A, Simpson, A, Johnston, SL & Custovic, A 2014, 'Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study', The lancet. Respiratory medicine, vol. 2, no. 8, pp. 621-630. https://doi.org/10.1016/S2213-2600(14)70096-7

Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study. / Ic-Jusufagic, Aida Sem; Belgrave, Danielle; Pickles, Andrew et al.
In: The lancet. Respiratory medicine, Vol. 2, No. 8, 08.2014, p. 621-630.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21

T2 - a population-based birth cohort study

AU - Ic-Jusufagic, Aida Sem

AU - Belgrave, Danielle

AU - Pickles, Andrew

AU - Telcian, Aurica G.

AU - Bakhsoliani, Eteri

AU - Sykes, Annemarie

AU - Simpson, Angela

AU - Johnston, Sebastian L.

AU - Custovic, Adnan

PY - 2014/8

Y1 - 2014/8

N2 - Background The relationship between early-life antibiotic use and the development of wheeze and asthma has been reported in several studies but might arise as a consequence of bias rather than causal relationship. We investigated the association between antibiotic prescription and subsequent development of atopy, wheeze, and asthma exacerbations, and the relation of early life antibiotic prescription with anti-infective immunity and genetic variants on asthma susceptibility locus 17q21.Methods Children in a population-based birth cohort were followed from birth to age 11 years. Information on antibiotic prescription, wheeze, and asthma exacerbations was extracted from medical records, and the effect of antibiotic prescription assessed with longitudinal analyses. We assessed immune responses of peripheral blood mononuclear cells, taken at age 11 years, to viruses (rhinovirus and respiratory syncytial virus; RSV) and bacteria (Haemophilus influenzae and Streptococcus pneumoniae) in children who either received at least one or no antibiotic prescriptions in infancy. Finally, we assessed the association of 17q21 polymorphisms with antibiotic prescription.Findings Of 984 families who gave consent, we extracted data for 916 children. We noted significantly higher risk of physician-confirmed wheezing after antibiotic prescription (hazard ratio [HR] 1.71,95% CI 1.32-2.23; pInterpretation The association between antibiotics and asthma might arise through a complex confounding by indication. Hidden factors that may increase the likelihood of both early life antibiotic prescription and later asthma are an increased susceptibility to viral infections consequent upon impaired antiviral immunity and genetic variants on 17q21.

AB - Background The relationship between early-life antibiotic use and the development of wheeze and asthma has been reported in several studies but might arise as a consequence of bias rather than causal relationship. We investigated the association between antibiotic prescription and subsequent development of atopy, wheeze, and asthma exacerbations, and the relation of early life antibiotic prescription with anti-infective immunity and genetic variants on asthma susceptibility locus 17q21.Methods Children in a population-based birth cohort were followed from birth to age 11 years. Information on antibiotic prescription, wheeze, and asthma exacerbations was extracted from medical records, and the effect of antibiotic prescription assessed with longitudinal analyses. We assessed immune responses of peripheral blood mononuclear cells, taken at age 11 years, to viruses (rhinovirus and respiratory syncytial virus; RSV) and bacteria (Haemophilus influenzae and Streptococcus pneumoniae) in children who either received at least one or no antibiotic prescriptions in infancy. Finally, we assessed the association of 17q21 polymorphisms with antibiotic prescription.Findings Of 984 families who gave consent, we extracted data for 916 children. We noted significantly higher risk of physician-confirmed wheezing after antibiotic prescription (hazard ratio [HR] 1.71,95% CI 1.32-2.23; pInterpretation The association between antibiotics and asthma might arise through a complex confounding by indication. Hidden factors that may increase the likelihood of both early life antibiotic prescription and later asthma are an increased susceptibility to viral infections consequent upon impaired antiviral immunity and genetic variants on 17q21.

KW - RESPIRATORY-INFECTIONS

KW - SUBSEQUENT DEVELOPMENT

KW - CHILDHOOD ASTHMA

KW - CHILDREN

KW - RISK

KW - EXPOSURE

KW - COMPLICATIONS

KW - PHENOTYPES

KW - PREGNANCY

KW - ALLERGY

U2 - 10.1016/S2213-2600(14)70096-7

DO - 10.1016/S2213-2600(14)70096-7

M3 - Article

SN - 2213-2600

VL - 2

SP - 621

EP - 630

JO - The lancet. Respiratory medicine

JF - The lancet. Respiratory medicine

IS - 8

ER -

Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study

Abstract

Keywords

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