Assessing the Impact of Blood Pressure on Cardiac Function Using Interpretable Biomarkers and Variational Autoencoders

Esther Puyol-Antón*, Bram Ruijsink, James R. Clough, Ilkay Oksuz, Daniel Rueckert, Reza Razavi, Andrew P. King

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

3 Citations (Scopus)
74 Downloads (Pure)

Abstract

Maintaining good cardiac function for as long as possible is a major concern for healthcare systems worldwide and there is much interest in learning more about the impact of different risk factors on cardiac health. The aim of this study is to analyze the impact of systolic blood pressure (SBP) on cardiac function while preserving the interpretability of the model using known clinical biomarkers in a large cohort of the UK Biobank population. We propose a novel framework that combines deep learning based estimation of interpretable clinical biomarkers from cardiac cine MR data with a variational autoencoder (VAE). The VAE architecture integrates a regression loss in the latent space, which enables the progression of cardiac health with SBP to be learnt. Results on 3,600 subjects from the UK Biobank show that the proposed model allows us to gain important insight into the deterioration of cardiac function with increasing SBP, identify key interpretable factors involved in this process, and lastly exploit the model to understand patterns of positive and adverse adaptation of cardiac function.

Original languageEnglish
Title of host publicationStatistical Atlases and Computational Models of the Heart. Multi-Sequence CMR Segmentation, CRT-EPiggy and LV Full Quantification Challenges - 10th International Workshop, STACOM 2019, Held in Conjunction with MICCAI 2019, Revised Selected Papers
EditorsMihaela Pop, Maxime Sermesant, Oscar Camara, Xiahai Zhuang, Shuo Li, Alistair Young, Tommaso Mansi, Avan Suinesiaputra
PublisherSPRINGER
Pages22-30
Number of pages9
ISBN (Print)9783030390730
DOIs
Publication statusPublished - 2020
Event10th International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2019, held in conjunction with the 22nd International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2019 - Shenzhen, China
Duration: 13 Oct 201913 Oct 2019

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume12009 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference10th International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2019, held in conjunction with the 22nd International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2019
Country/TerritoryChina
CityShenzhen
Period13/10/201913/10/2019

Keywords

  • Cardiac function
  • Cardiac risk factors
  • Variational autoencoder

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