Assessing within-subject rates of change of placental MRI diffusion metrics in normal pregnancy

Daniel Cromb, Paddy J. Slator, Miguel De La Fuente, Anthony N. Price, Mary Rutherford, Alexia Egloff, Serena J. Counsell*, Jana Hutter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Purpose: Studying placental development informs when development is abnormal. Most placental MRI studies are cross-sectional and do not study the extent of individual variability throughout pregnancy. We aimed to explore how diffusion MRI measures of placental function and microstructure vary in individual healthy pregnancies throughout gestation. Methods: Seventy-nine pregnant, low-risk participants (17 scanned twice and 62 scanned once) were included. T2-weighted anatomical imaging and a combined multi-echo spin-echo diffusion-weighted sequence were acquired at 3 T. Combined diffusion–relaxometry models were performed using both a (Figure presented.) -ADC and a bicompartmental (Figure presented.) -intravoxel-incoherent-motion ((Figure presented.)) model fit. Results: There was a significant decline in placental (Figure presented.) and ADC (both P < 0.01) over gestation. These declines are consistent in individuals for (Figure presented.) (covariance = −0.47), but not ADC (covariance = −1.04). The (Figure presented.) model identified a consistent decline in individuals over gestation in (Figure presented.) from both the perfusing and diffusing placental compartments, but not in ADC values from either. The placental perfusing compartment fraction increased over gestation (P = 0.0017), but this increase was not consistent in individuals (covariance = 2.57). Conclusion: Whole placental (Figure presented.) and ADC values decrease over gestation, although only (Figure presented.) values showed consistent trends within subjects. There was minimal individual variation in rates of change of (Figure presented.) values from perfusing and diffusing placental compartments, whereas trends in ADC values from these compartments were less consistent. These findings probably relate to the increased complexity of the bicompartmental (Figure presented.) model, and differences in how different placental regions evolve at a microstructural level. These placental MRI metrics from low-risk pregnancies provide a useful benchmark for clinical cohorts.

Original languageEnglish
Pages (from-to)1137-1150
Number of pages14
JournalMagnetic Resonance in Medicine
Volume90
Issue number3
DOIs
Publication statusPublished - Sept 2023

Keywords

  • diffusion imaging
  • longitudinal imaging
  • placental MRI
  • relaxometry

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