Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry: EFSA Journal

D. Schrenk; M. Bignami; L. Bodin; J.K.C.J. del Mazo; B. Grasl-Kraupp; C. Hogstrand; J.-C. Leblanc; E. Nielsen; E. Ntzani; A. Petersen; S. Sand; T. Schwerdtle; C. Vleminckx; H. Wallace; S. Dänicke; C.S. Nebbia; I.P. Oswald; E. Rovesti; H. Steinkellner; L. Hoogenboom; EFSA Panelon Contaminants in the Food Chain (contam)

doi:10.2903/j.efsa.2023.7806

Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry: EFSA Journal

D. Schrenk, M. Bignami, L. Bodin, J.K.C.J. del Mazo, B. Grasl-Kraupp, C. Hogstrand, J.-C. Leblanc, E. Nielsen, E. Ntzani, A. Petersen, S. Sand, T. Schwerdtle, C. Vleminckx, H. Wallace, S. Dänicke, C.S. Nebbia, I.P. Oswald, E. Rovesti, H. Steinkellner, L. HoogenboomEFSA Panelon Contaminants in the Food Chain (contam)

Research output: Contribution to journal › Article › peer-review

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Abstract

In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low.

Original language	English
Article number	e07806
Journal	EFSA J.
Volume	21
Issue number	2
DOIs	https://doi.org/10.2903/j.efsa.2023.7806
Publication status	Published - Feb 2023

Keywords

animal health risk assessment
deoxynivalenol
DON
exposure
horses
poultry
toxicity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2903/j.efsa.2023.7806

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85150933084&doi=10.2903%2fj.efsa.2023.7806&partnerID=40&md5=d8cd2f5a88c29d6c4743374df63f0c91

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Schrenk, D., Bignami, M., Bodin, L., del Mazo, J. K. C. J., Grasl-Kraupp, B., Hogstrand, C., Leblanc, J.-C., Nielsen, E., Ntzani, E., Petersen, A., Sand, S., Schwerdtle, T., Vleminckx, C., Wallace, H., Dänicke, S., Nebbia, C. S., Oswald, I. P., Rovesti, E., Steinkellner, H., ... (contam), EFSA. P. C. I. T. F. C. (2023). Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry: EFSA Journal. EFSA J., 21(2), Article e07806. https://doi.org/10.2903/j.efsa.2023.7806

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title = "Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry: EFSA Journal",

abstract = "In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low.",

keywords = "animal health risk assessment, deoxynivalenol, DON, exposure, horses, poultry, toxicity",

author = "D. Schrenk and M. Bignami and L. Bodin and {del Mazo}, J.K.C.J. and B. Grasl-Kraupp and C. Hogstrand and J.-C. Leblanc and E. Nielsen and E. Ntzani and A. Petersen and S. Sand and T. Schwerdtle and C. Vleminckx and H. Wallace and S. D{\"a}nicke and C.S. Nebbia and I.P. Oswald and E. Rovesti and H. Steinkellner and L. Hoogenboom and (contam), {EFSA Panelon Contaminants in the Food Chain}",

note = "Publisher Copyright: {\textcopyright} 2023 European Food Safety Authority. EFSA Journal published by Wiley-VCH GmbH on behalf of European Food Safety Authority.",

year = "2023",

month = feb,

doi = "10.2903/j.efsa.2023.7806",

language = "English",

volume = "21",

journal = "EFSA J.",

issn = "1831-4732",

publisher = "John Wiley and Sons Inc.",

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Schrenk, D, Bignami, M, Bodin, L, del Mazo, JKCJ, Grasl-Kraupp, B, Hogstrand, C, Leblanc, J-C, Nielsen, E, Ntzani, E, Petersen, A, Sand, S, Schwerdtle, T, Vleminckx, C, Wallace, H, Dänicke, S, Nebbia, CS, Oswald, IP, Rovesti, E, Steinkellner, H, Hoogenboom, L & (contam), EFSAPCITFC 2023, 'Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry: EFSA Journal', EFSA J., vol. 21, no. 2, e07806. https://doi.org/10.2903/j.efsa.2023.7806

TY - JOUR

T1 - Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry

T2 - EFSA Journal

AU - Schrenk, D.

AU - Bignami, M.

AU - Bodin, L.

AU - del Mazo, J.K.C.J.

AU - Grasl-Kraupp, B.

AU - Hogstrand, C.

AU - Leblanc, J.-C.

AU - Nielsen, E.

AU - Ntzani, E.

AU - Petersen, A.

AU - Sand, S.

AU - Schwerdtle, T.

AU - Vleminckx, C.

AU - Wallace, H.

AU - Dänicke, S.

AU - Nebbia, C.S.

AU - Oswald, I.P.

AU - Rovesti, E.

AU - Steinkellner, H.

AU - Hoogenboom, L.

AU - (contam), EFSA Panelon Contaminants in the Food Chain

PY - 2023/2

Y1 - 2023/2

N2 - In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low.

AB - In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low.

KW - animal health risk assessment

KW - deoxynivalenol

KW - DON

KW - exposure

KW - horses

KW - poultry

KW - toxicity

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U2 - 10.2903/j.efsa.2023.7806

DO - 10.2903/j.efsa.2023.7806

M3 - Article

SN - 1831-4732

VL - 21

JO - EFSA J.

JF - EFSA J.

IS - 2

M1 - e07806

ER -

Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry: EFSA Journal

Abstract

Keywords

UN SDGs

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