Assessment of long chain n-3 polyunsaturated fatty acid status and clinical outcome in adults receiving home parenteral nutrition

David A J Lloyd, Sarah E. Paynton, Paul Bassett, Anna Rodriguez Mateos, Julie A. Lovegrove, Simon M. Gabe, Bruce A. Griffin

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background & aims: Long term parenteral nutrition rarely supplies the long chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA). The aim of this study was to assess long chain n-3 PUFA status in patients receiving home parenteral nutrition (HPN). Methods: Plasma phospholipid fatty acids were measured in 64 adult HPN patients and compared with 54 age, sex and BMI matched controls. Logistic regression analysis was used to identify factors related to plasma fatty acid fractions in the HPN patients, and to identify factors associated with the risk of clinical complications. Results: Plasma phospholipid fractions of EPA, DPA and DHA were significantly lower in patients receiving HPN. Factors independently associated with low fractions included high parenteral energy provision, low parenteral lipid intake, low BMI and prolonged duration of HPN. Long chain n-3 PUFA fractions were not associated with incidence of either central venous catheter associated infection or central venous thrombosis. However, the fraction of EPA were inversely associated with plasma alkaline phosphatase concentrations. Conclusions: This study demonstrates abnormal long chain n-3 PUFA profiles in patients receiving HPN. Reduced fatty acid intake may be partly responsible. Fatty acid metabolism may also be altered. © 2008 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.
Original languageEnglish
Pages (from-to)822-831
Number of pages10
Publication statusPublished - Dec 2008


  • Complications
  • Fatty acid
  • Fish oils
  • HPN
  • Parenteral nutrition
  • n-3 PUFA


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