Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population

E W Loh; S Higuchi; S Matsushita; R Murray; C K Chen; D Ball

doi:10.1038/sj.mp.4000719

Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population

E W Loh, S Higuchi, S Matsushita, R Murray, C K Chen, D Ball

Research output: Contribution to journal › Article › peer-review

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Abstract

Recent investigations suggest that genetic susceptibility to alcohol dependence may be conferred by GABA(A) receptor subunit genes. In this study, three RFLPs at the GABA(A)beta 2 GABA(A)alpha 6, GABA(A)alpha 1 and two at the GABA(A)gamma 2 receptor subunit genes, were examined for association with alcohol dependence in 189 subjects meeting DSM-III-R criteria for this disorder and 152 unrelated controls from a Japanese population. The results demonstrated no association between the AlwNI RFLP at the GABA(A)alpha 6 receptor subunit gene and alcohol dependence (P = 0,059), However, the NciI RFLP at the GABA(A)gamma 2 receptor subunit gene was associated with alcohol dependence comorbid with antisocial personality disorder (P = 0.021), This supports a recent finding reporting an association between the GABA(A)gamma 2 receptor subunit gene and alcohol dependence with criminal record in a Finnish population. Taking into account the effects of multiple comparisons, this result should be interpreted with caution pending replication.

Original language	English
Pages (from-to)	301 - 307
Number of pages	7
Journal	Molecular Psychiatry
Volume	5
Issue number	3
DOIs	https://doi.org/10.1038/sj.mp.4000719
Publication status	Published - 2000

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title = "Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population",

abstract = "Recent investigations suggest that genetic susceptibility to alcohol dependence may be conferred by GABA(A) receptor subunit genes. In this study, three RFLPs at the GABA(A)beta 2 GABA(A)alpha 6, GABA(A)alpha 1 and two at the GABA(A)gamma 2 receptor subunit genes, were examined for association with alcohol dependence in 189 subjects meeting DSM-III-R criteria for this disorder and 152 unrelated controls from a Japanese population. The results demonstrated no association between the AlwNI RFLP at the GABA(A)alpha 6 receptor subunit gene and alcohol dependence (P = 0,059), However, the NciI RFLP at the GABA(A)gamma 2 receptor subunit gene was associated with alcohol dependence comorbid with antisocial personality disorder (P = 0.021), This supports a recent finding reporting an association between the GABA(A)gamma 2 receptor subunit gene and alcohol dependence with criminal record in a Finnish population. Taking into account the effects of multiple comparisons, this result should be interpreted with caution pending replication.",

author = "Loh, {E W} and S Higuchi and S Matsushita and R Murray and Chen, {C K} and D Ball",

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doi = "10.1038/sj.mp.4000719",

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T1 - Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population

AU - Loh, E W

AU - Higuchi, S

AU - Matsushita, S

AU - Murray, R

AU - Chen, C K

AU - Ball, D

PY - 2000

Y1 - 2000

N2 - Recent investigations suggest that genetic susceptibility to alcohol dependence may be conferred by GABA(A) receptor subunit genes. In this study, three RFLPs at the GABA(A)beta 2 GABA(A)alpha 6, GABA(A)alpha 1 and two at the GABA(A)gamma 2 receptor subunit genes, were examined for association with alcohol dependence in 189 subjects meeting DSM-III-R criteria for this disorder and 152 unrelated controls from a Japanese population. The results demonstrated no association between the AlwNI RFLP at the GABA(A)alpha 6 receptor subunit gene and alcohol dependence (P = 0,059), However, the NciI RFLP at the GABA(A)gamma 2 receptor subunit gene was associated with alcohol dependence comorbid with antisocial personality disorder (P = 0.021), This supports a recent finding reporting an association between the GABA(A)gamma 2 receptor subunit gene and alcohol dependence with criminal record in a Finnish population. Taking into account the effects of multiple comparisons, this result should be interpreted with caution pending replication.

AB - Recent investigations suggest that genetic susceptibility to alcohol dependence may be conferred by GABA(A) receptor subunit genes. In this study, three RFLPs at the GABA(A)beta 2 GABA(A)alpha 6, GABA(A)alpha 1 and two at the GABA(A)gamma 2 receptor subunit genes, were examined for association with alcohol dependence in 189 subjects meeting DSM-III-R criteria for this disorder and 152 unrelated controls from a Japanese population. The results demonstrated no association between the AlwNI RFLP at the GABA(A)alpha 6 receptor subunit gene and alcohol dependence (P = 0,059), However, the NciI RFLP at the GABA(A)gamma 2 receptor subunit gene was associated with alcohol dependence comorbid with antisocial personality disorder (P = 0.021), This supports a recent finding reporting an association between the GABA(A)gamma 2 receptor subunit gene and alcohol dependence with criminal record in a Finnish population. Taking into account the effects of multiple comparisons, this result should be interpreted with caution pending replication.

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Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population

Abstract

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