Association at SYNE1 in both bipolar disorder and recurrent major depression

TY - JOUR

T1 - Association at SYNE1 in both bipolar disorder and recurrent major depression

AU - Green, E. K.

AU - Grozeva, D.

AU - Forty, L.

AU - Gordon-Smith, K.

AU - Russell, E.

AU - Farmer, A.

AU - Hamshere, M.

AU - Jones, I. R.

AU - Jones, L.

AU - McGuffin, P.

AU - Moran, J. L.

AU - Purcell, S.

AU - Sklar, P.

AU - Owen, M. J.

AU - O'Donovan, M. C.

AU - Craddock, N.

PY - 2013/5

Y1 - 2013/5

N2 - Genome-wide association studies (GWAS) have identified a number of loci that have strong support for their association with bipolar disorder (BD). The Psychiatric Genome-Wide Association Study (GWAS) Consortium Bipolar Disorder Working Group (PGC-BD) meta-analysis of BD GWAS data sets and replication samples identified evidence (P = 6.7 x 10(-7), odds ratio (OR) = 1.147) of association with the risk of BD at the polymorphism rs9371601 within SYNE1, a gene which encodes nesprin-1. Here we have tested this polymorphism in an independent BD case (n = 1527) and control (n = 1579) samples, and find evidence for association (P = 0.0095) with similar effect sizes to those previously observed in BD (allelic OR = 1.148). In a combined (meta) analysis of PGC-BD data (both primary and replication data) and our independent BD samples, we found genome-wide significant evidence for association (P = 2.9 x 10(-8), OR = 1.104). We have also examined the polymorphism in our recurrent unipolar depression cases (n = 1159) and control (n = 2592) sample, and found that the risk allele was associated with risk for recurrent major depression (P = 0.032, OR = 1.118). Our findings add to the evidence that association at this locus influences susceptibility to bipolar and unipolar mood disorders. Molecular Psychiatry (2013) 18, 614-617; doi:10.1038/mp.2012.48; published online 8 May 2012

AB - Genome-wide association studies (GWAS) have identified a number of loci that have strong support for their association with bipolar disorder (BD). The Psychiatric Genome-Wide Association Study (GWAS) Consortium Bipolar Disorder Working Group (PGC-BD) meta-analysis of BD GWAS data sets and replication samples identified evidence (P = 6.7 x 10(-7), odds ratio (OR) = 1.147) of association with the risk of BD at the polymorphism rs9371601 within SYNE1, a gene which encodes nesprin-1. Here we have tested this polymorphism in an independent BD case (n = 1527) and control (n = 1579) samples, and find evidence for association (P = 0.0095) with similar effect sizes to those previously observed in BD (allelic OR = 1.148). In a combined (meta) analysis of PGC-BD data (both primary and replication data) and our independent BD samples, we found genome-wide significant evidence for association (P = 2.9 x 10(-8), OR = 1.104). We have also examined the polymorphism in our recurrent unipolar depression cases (n = 1159) and control (n = 2592) sample, and found that the risk allele was associated with risk for recurrent major depression (P = 0.032, OR = 1.118). Our findings add to the evidence that association at this locus influences susceptibility to bipolar and unipolar mood disorders. Molecular Psychiatry (2013) 18, 614-617; doi:10.1038/mp.2012.48; published online 8 May 2012

KW - SYNE1

KW - bipolar disorder

KW - unipolar depression

KW - genetics

KW - rs9371601

KW - GENOME-WIDE ASSOCIATION

KW - SCHIZOPHRENIA

KW - RELIABILITY

KW - RATIONALE

KW - CRITERIA

KW - LOCI

U2 - 10.1038/mp.2012.48

DO - 10.1038/mp.2012.48

M3 - Article

SN - 1359-4184

VL - 18

SP - 614

EP - 617

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 5

ER -