Association between baseline serum glucose, triglycerides and total cholesterol, and prostate cancer risk categories

Rhonda Arthur, Henrik Møller, Hans Garmo, Lars Holmberg, Pår Stattin, Håkan Malmstrom, Mats Lambe, Niklas Hammar, Göran Walldius, David Robinson, Ingmar Jungner, Mieke Van Hemelrijck

    Research output: Contribution to journalArticlepeer-review

    42 Citations (Scopus)
    257 Downloads (Pure)

    Abstract

    Lifestyle-related risk factors such as hyperglycemia and dyslipidemia have been associated with several cancers. However, studies exploring their link with prostate cancer (PCa) clinicopathological characteristics are sparse and inconclusive. Here, we investigated the associations between serum metabolic markers and PCa clinicopathological characteristics. The study comprised 14,294 men from the Swedish Apolipoprotein MOrtality RISk (AMORIS) cohort who were diagnosed with PCa between 1996 and 2011. Univariate and multivariable logistic regression were used to investigate the relation between glucose, triglycerides and total cholesterol and PCa risk categories, PSA, Gleason score, and T-stage. Mean age at time of PCa diagnosis was 69 years. Men with glucose levels >6.9 mmol/L tend to have PSA<4 μg/L, while those with glucose levels of 5.6-6.9 mmol/L had a greater odds of PSA>20 μg/L compared to PSA 4.0-9.9 μg/L. Hypertriglyceridemia was also positively associated with PSA>20 μg/L. Hyperglycemic men had a greater odds of intermediate- and high-grade PCa and advanced stage or metastatic PCa. Similarly, hypertriglyceridemia was positively associated with high-grade PCa. There was also a trend toward an increased odds of intermediate risk localized PCa and advanced stage PCa among men with hypertriglyceridemia. Total cholesterol did not have any statistically significant association with any of the outcomes studied. Our findings suggest that high serum levels of glucose and triglycerides may influence PCa aggressiveness and severity. Further investigation on the role of markers of glucose and lipid metabolism in influencing PCa aggressiveness and severity is needed as this may help define important targets for intervention.

    Original languageEnglish
    Pages (from-to)1307–1318
    JournalCancer Research
    Volume5
    Issue number6
    Early online date29 Feb 2016
    DOIs
    Publication statusPublished - Jun 2016

    Fingerprint

    Dive into the research topics of 'Association between baseline serum glucose, triglycerides and total cholesterol, and prostate cancer risk categories'. Together they form a unique fingerprint.

    Cite this