Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry

TY - JOUR

T1 - Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry

AU - Lopes, Luis R.

AU - Losi, Maria Angela

AU - Sheikh, Nabeel

AU - Laroche, Cécile

AU - Charron, Philippe

AU - Gimeno, Juan

AU - Kaski, Juan P.

AU - Maggioni, Aldo P.

AU - Tavazzi, Luigi

AU - Arbustini, Eloisa

AU - Brito, Duke

AU - Celutkiene, Jelena

AU - Hagege, Albert

AU - Linhart, Ales

AU - Mogensen, Jens

AU - Garcia-Pinilla, José Manuel

AU - Ripoll-Vera, Tomas

AU - Seggewiss, Hubert

AU - Villacorta, Eduardo

AU - Caforio, Alida

AU - Elliott, Perry M.

AU - Gale, Christopher Peter

AU - Beleslin, Branko

AU - Bu-Daj, Andrzej

AU - Chioncel, Ovidiu

AU - Dagres, Nikolaos

AU - Danchin, Nicolas

AU - Erlinge, David

AU - Ali, M.

AU - Arslan, M.

AU - Tissot, C. M.

AU - Bauer, A.

AU - Pedersen, A. L.

AU - Iqbal, H.

AU - Carr-White, G.

AU - Bueser, T.

AU - Rajani, R.

AU - Clack, L.

AU - Jones, S.

AU - Smith, M.

AU - Wilson, K.

AU - Amin, A.

AU - Longhi, S.

AU - Russo, M. G.

AU - Esposito, A.

AU - Serio, A.

AU - Almeida, A. R.

AU - Gomes, A. C.

AU - Pereira, A. R.

AU - Gonzalez, J.

AU - the Cardiomyopathy Registry Investigators Group

N1 - Publisher Copyright: © The Author(s) 2022.

PY - 2023/2/9

Y1 - 2023/2/9

N2 - Aims The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry Methods and results: 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (P<0.001), less family history of HCM (HT and DM P<0.001), higher New York Heart Association (NYHA) class (P<0.001), atrial fibrillation (HT and DM P<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob P<0.001; DM P = 0.003). Stroke was more frequent in HT (P<0.001) and mutation-positive patients with DM (P = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT P<0.001, Ob P = 0.036). LV hypertrophy was more severe in Ob (P = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, P = 0.017 and OR 1.584, P = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients. Conclusion Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits.

AB - Aims The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry Methods and results: 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (P<0.001), less family history of HCM (HT and DM P<0.001), higher New York Heart Association (NYHA) class (P<0.001), atrial fibrillation (HT and DM P<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob P<0.001; DM P = 0.003). Stroke was more frequent in HT (P<0.001) and mutation-positive patients with DM (P = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT P<0.001, Ob P = 0.036). LV hypertrophy was more severe in Ob (P = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, P = 0.017 and OR 1.584, P = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients. Conclusion Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits.

KW - Cardiovascular risk factors

KW - Diabetes

KW - Genotype

KW - Hypertension

KW - Hypertrophic cardiomyopathy

KW - Obesity

UR - https://www.scopus.com/pages/publications/85136423278

U2 - 10.1093/ehjqcco/qcac006

DO - 10.1093/ehjqcco/qcac006

M3 - Article

C2 - 35138368

AN - SCOPUS:85136423278

SN - 2058-5225

VL - 9

SP - 42

EP - 53

JO - European Heart Journal - Quality of Care and Clinical Outcomes

JF - European Heart Journal - Quality of Care and Clinical Outcomes

IS - 1

ER -