Association between idiopathic infantile macrocephaly and autism spectrum disorders

P F Bolton; M Roobol; L Allsopp; A Pickles

doi:10.1016/S0140-6736(01)05903-7

Association between idiopathic infantile macrocephaly and autism spectrum disorders

P F Bolton
, M Roobol
, L Allsopp
, A Pickles

Research output: Contribution to journal › Letter › peer-review

54 Citations (Scopus)

Abstract

We conducted a case-controlled, catch-up study of a cohort of boys born with macrocephaly in order to determine whether infantile macrocephaly is a risk marker for the later development of autism spectrum disorders. Our results show that infantile macrocephaly was associated with an increased risk of developing autism spectrum disorders (odds ratio 5.44, 95% CI 1.11-52.15; p=0.03). These findings suggest that neurobiological differences during infancy may predict behavioural manifestations of autism spectrum disorders

Original language	English
Pages (from-to)	726 - 727
Number of pages	2
Journal	The Lancet
Volume	358
Issue number	9283
DOIs	https://doi.org/10.1016/S0140-6736(01)05903-7
Publication status	Published - 1 Sept 2001

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title = "Association between idiopathic infantile macrocephaly and autism spectrum disorders",

abstract = "We conducted a case-controlled, catch-up study of a cohort of boys born with macrocephaly in order to determine whether infantile macrocephaly is a risk marker for the later development of autism spectrum disorders. Our results show that infantile macrocephaly was associated with an increased risk of developing autism spectrum disorders (odds ratio 5.44, 95\% CI 1.11-52.15; p=0.03). These findings suggest that neurobiological differences during infancy may predict behavioural manifestations of autism spectrum disorders",

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T1 - Association between idiopathic infantile macrocephaly and autism spectrum disorders

AU - Bolton, P F

AU - Roobol, M

AU - Allsopp, L

AU - Pickles, A

PY - 2001/9/1

Y1 - 2001/9/1

N2 - We conducted a case-controlled, catch-up study of a cohort of boys born with macrocephaly in order to determine whether infantile macrocephaly is a risk marker for the later development of autism spectrum disorders. Our results show that infantile macrocephaly was associated with an increased risk of developing autism spectrum disorders (odds ratio 5.44, 95% CI 1.11-52.15; p=0.03). These findings suggest that neurobiological differences during infancy may predict behavioural manifestations of autism spectrum disorders

AB - We conducted a case-controlled, catch-up study of a cohort of boys born with macrocephaly in order to determine whether infantile macrocephaly is a risk marker for the later development of autism spectrum disorders. Our results show that infantile macrocephaly was associated with an increased risk of developing autism spectrum disorders (odds ratio 5.44, 95% CI 1.11-52.15; p=0.03). These findings suggest that neurobiological differences during infancy may predict behavioural manifestations of autism spectrum disorders

U2 - 10.1016/S0140-6736(01)05903-7

DO - 10.1016/S0140-6736(01)05903-7

M3 - Letter

SN - 1474-547X

VL - 358

SP - 726

EP - 727

JO - The Lancet

JF - The Lancet

IS - 9283

ER -

Association between idiopathic infantile macrocephaly and autism spectrum disorders

Abstract

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