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Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease

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Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease. / Kim, Min; Nevado-Holgado, Alejo; Whiley, Luke; Snowden, Stuart G.; Soininen, Hilkka; Kloszewska, Iwona; Mecocci, Patrizia; Tsolaki, Magda; Vellas, Bruno; Thambisetty, Madhav; Dobson, Richard J. B.; Powell, John E.; Lupton, Michelle K.; Simmons, Andy; Velayudhan, Latha; Lovestone, Simon; Proitsi, Petroula; Legido-Quigley, Cristina.

In: JOURNAL OF ALZHEIMERS DISEASE, Vol. 60, No. 3, 03.10.2017, p. 809-817.

Research output: Contribution to journalArticle

Harvard

Kim, M, Nevado-Holgado, A, Whiley, L, Snowden, SG, Soininen, H, Kloszewska, I, Mecocci, P, Tsolaki, M, Vellas, B, Thambisetty, M, Dobson, RJB, Powell, JE, Lupton, MK, Simmons, A, Velayudhan, L, Lovestone, S, Proitsi, P & Legido-Quigley, C 2017, 'Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease', JOURNAL OF ALZHEIMERS DISEASE, vol. 60, no. 3, pp. 809-817. https://doi.org/10.3233/JAD-160645

APA

Kim, M., Nevado-Holgado, A., Whiley, L., Snowden, S. G., Soininen, H., Kloszewska, I., ... Legido-Quigley, C. (2017). Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE, 60(3), 809-817. https://doi.org/10.3233/JAD-160645

Vancouver

Kim M, Nevado-Holgado A, Whiley L, Snowden SG, Soininen H, Kloszewska I et al. Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE. 2017 Oct 3;60(3):809-817. https://doi.org/10.3233/JAD-160645

Author

Kim, Min ; Nevado-Holgado, Alejo ; Whiley, Luke ; Snowden, Stuart G. ; Soininen, Hilkka ; Kloszewska, Iwona ; Mecocci, Patrizia ; Tsolaki, Magda ; Vellas, Bruno ; Thambisetty, Madhav ; Dobson, Richard J. B. ; Powell, John E. ; Lupton, Michelle K. ; Simmons, Andy ; Velayudhan, Latha ; Lovestone, Simon ; Proitsi, Petroula ; Legido-Quigley, Cristina. / Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease. In: JOURNAL OF ALZHEIMERS DISEASE. 2017 ; Vol. 60, No. 3. pp. 809-817.

Bibtex Download

@article{ef4718904e114f63b14288021a865f2c,
title = "Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease",
abstract = "Lipids such as ceramides (Cer) and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer's disease (AD) patients in a number of discovery studies. For this reason, the levels of 6 ceramides and 3 PCs, with different fatty acid length and saturation levels, were measured in the plasma from 412 participants (AD n = 205, Control n = 207) using mass spectrometry coupled with ultra-performance liquid chromatography. After this, associations with AD status, brain atrophy, and age-related effects were studied. In the plasma of AD participants, cross-sectional analysis revealed elevated levels of three ceramides (Cer16:0 p < 0.01, Cer18:0 p < 0.01, Cer24:1 p < 0.05). In addition, two PCs in AD plasma (PC36:5 p < 0.05, PC38:6 p < 0.05) were found to be depleted compared to the control group, with PC36:5 also associating with hippocampal atrophy (p < 0.01). Age-specific analysis further revealed that levels of Cer16:0, Cer18:0, and Cer20:0 were associated with hippocampal atrophy only in younger participants (age < 75, p < 0.05), while all 3 PCs did so in the older participants (age > 75, p < 0.05). PC36:5 was associated with AD status in the younger group (p < 0.01), while PC38:6 and 40:6 did so in the older group (p < 0.05). In this study, elevated ceramides and depleted PCs were found in the plasma from 205 AD volunteers. Our findings also suggest that dysregulation in PC and ceramide metabolism could be occurring in different stages of AD progression.",
keywords = "Alzheimer's disease, brain atrophy, ceramide, phosphatidylcholine",
author = "Min Kim and Alejo Nevado-Holgado and Luke Whiley and Snowden, {Stuart G.} and Hilkka Soininen and Iwona Kloszewska and Patrizia Mecocci and Magda Tsolaki and Bruno Vellas and Madhav Thambisetty and Dobson, {Richard J. B.} and Powell, {John E.} and Lupton, {Michelle K.} and Andy Simmons and Latha Velayudhan and Simon Lovestone and Petroula Proitsi and Cristina Legido-Quigley",
year = "2017",
month = "10",
day = "3",
doi = "10.3233/JAD-160645",
language = "English",
volume = "60",
pages = "809--817",
journal = "JOURNAL OF ALZHEIMERS DISEASE",
issn = "1387-2877",
number = "3",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease

AU - Kim, Min

AU - Nevado-Holgado, Alejo

AU - Whiley, Luke

AU - Snowden, Stuart G.

AU - Soininen, Hilkka

AU - Kloszewska, Iwona

AU - Mecocci, Patrizia

AU - Tsolaki, Magda

AU - Vellas, Bruno

AU - Thambisetty, Madhav

AU - Dobson, Richard J. B.

AU - Powell, John E.

AU - Lupton, Michelle K.

AU - Simmons, Andy

AU - Velayudhan, Latha

AU - Lovestone, Simon

AU - Proitsi, Petroula

AU - Legido-Quigley, Cristina

PY - 2017/10/3

Y1 - 2017/10/3

N2 - Lipids such as ceramides (Cer) and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer's disease (AD) patients in a number of discovery studies. For this reason, the levels of 6 ceramides and 3 PCs, with different fatty acid length and saturation levels, were measured in the plasma from 412 participants (AD n = 205, Control n = 207) using mass spectrometry coupled with ultra-performance liquid chromatography. After this, associations with AD status, brain atrophy, and age-related effects were studied. In the plasma of AD participants, cross-sectional analysis revealed elevated levels of three ceramides (Cer16:0 p < 0.01, Cer18:0 p < 0.01, Cer24:1 p < 0.05). In addition, two PCs in AD plasma (PC36:5 p < 0.05, PC38:6 p < 0.05) were found to be depleted compared to the control group, with PC36:5 also associating with hippocampal atrophy (p < 0.01). Age-specific analysis further revealed that levels of Cer16:0, Cer18:0, and Cer20:0 were associated with hippocampal atrophy only in younger participants (age < 75, p < 0.05), while all 3 PCs did so in the older participants (age > 75, p < 0.05). PC36:5 was associated with AD status in the younger group (p < 0.01), while PC38:6 and 40:6 did so in the older group (p < 0.05). In this study, elevated ceramides and depleted PCs were found in the plasma from 205 AD volunteers. Our findings also suggest that dysregulation in PC and ceramide metabolism could be occurring in different stages of AD progression.

AB - Lipids such as ceramides (Cer) and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer's disease (AD) patients in a number of discovery studies. For this reason, the levels of 6 ceramides and 3 PCs, with different fatty acid length and saturation levels, were measured in the plasma from 412 participants (AD n = 205, Control n = 207) using mass spectrometry coupled with ultra-performance liquid chromatography. After this, associations with AD status, brain atrophy, and age-related effects were studied. In the plasma of AD participants, cross-sectional analysis revealed elevated levels of three ceramides (Cer16:0 p < 0.01, Cer18:0 p < 0.01, Cer24:1 p < 0.05). In addition, two PCs in AD plasma (PC36:5 p < 0.05, PC38:6 p < 0.05) were found to be depleted compared to the control group, with PC36:5 also associating with hippocampal atrophy (p < 0.01). Age-specific analysis further revealed that levels of Cer16:0, Cer18:0, and Cer20:0 were associated with hippocampal atrophy only in younger participants (age < 75, p < 0.05), while all 3 PCs did so in the older participants (age > 75, p < 0.05). PC36:5 was associated with AD status in the younger group (p < 0.01), while PC38:6 and 40:6 did so in the older group (p < 0.05). In this study, elevated ceramides and depleted PCs were found in the plasma from 205 AD volunteers. Our findings also suggest that dysregulation in PC and ceramide metabolism could be occurring in different stages of AD progression.

KW - Alzheimer's disease

KW - brain atrophy

KW - ceramide

KW - phosphatidylcholine

UR - http://www.scopus.com/inward/record.url?scp=85030635122&partnerID=8YFLogxK

U2 - 10.3233/JAD-160645

DO - 10.3233/JAD-160645

M3 - Article

C2 - 27911300

VL - 60

SP - 809

EP - 817

JO - JOURNAL OF ALZHEIMERS DISEASE

JF - JOURNAL OF ALZHEIMERS DISEASE

SN - 1387-2877

IS - 3

ER -

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