Association between prenatal antipsychotic exposure and the risk of attention-deficit/hyperactivity disorder and autism spectrum disorder: a systematic review and meta-analysis

TY - JOUR

T1 - Association between prenatal antipsychotic exposure and the risk of attention-deficit/hyperactivity disorder and autism spectrum disorder

T2 - a systematic review and meta-analysis

AU - Wang, Zixuan

AU - Yuen, Andrew SC

AU - Wong, Kirstie HTW

AU - Chan, Adrienne YL

AU - Coghill, David

AU - Simonoff, Emily

AU - Lau, Wallis CY

AU - Wong, Ian CK

AU - Park, Sohee

AU - Man, Kenneth KC

N1 - Publisher Copyright: © 2024 The Authors

PY - 2024/5

Y1 - 2024/5

N2 - The paucity of evidence regarding the safety of gestational antipsychotic exposure has led to treatment discontinuation in pregnant women with severe mental health conditions. This systematic review and meta-analysis aimed to summarise the current evidence on the association between gestational antipsychotic exposure and attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in children (Study protocol registered in PROSPERO:CRD42022311354). Five studies included in our meta-analysis with around 8.6 million pregnancy episodes in nine different countries/regions. Results from our meta-analysis indicate that the heightened risks of ASD and ADHD in children gestationally exposed to antipsychotics appear to be attributable to maternal characteristics, rather than having a causal relationship with the antipsychotic exposure during pregnancy. The results underscore the importance of meticulously monitoring the neurodevelopment of children born to mothers with mental illnesses, which can facilitate early interventions and provide requisite support.

AB - The paucity of evidence regarding the safety of gestational antipsychotic exposure has led to treatment discontinuation in pregnant women with severe mental health conditions. This systematic review and meta-analysis aimed to summarise the current evidence on the association between gestational antipsychotic exposure and attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in children (Study protocol registered in PROSPERO:CRD42022311354). Five studies included in our meta-analysis with around 8.6 million pregnancy episodes in nine different countries/regions. Results from our meta-analysis indicate that the heightened risks of ASD and ADHD in children gestationally exposed to antipsychotics appear to be attributable to maternal characteristics, rather than having a causal relationship with the antipsychotic exposure during pregnancy. The results underscore the importance of meticulously monitoring the neurodevelopment of children born to mothers with mental illnesses, which can facilitate early interventions and provide requisite support.

KW - Antipsychotic

KW - Attention-deficit/hyperactivity disorder

KW - Autism spectrum disorder

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85188067116&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2024.105635

DO - 10.1016/j.neubiorev.2024.105635

M3 - Review article

C2 - 38499117

AN - SCOPUS:85188067116

SN - 0149-7634

VL - 160

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

M1 - 105635

ER -