Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants.

Linda Broer; Julia Raschenberger; Joris Deelen; Massimo Mangino; Veryan Codd; Kirsi H. Pietiläinen; Eva Albrecht; Najaf Amin; Marian Beekman; Anton J M de Craen; Christian Gieger; Margot Haun; Peter Henneman; Christian Herder; Iiris Hovatta; Annika Laser; Lyudmyla Kedenko; Wolfgang Koenig; Barbara Kollerits; Eeva Moilanen; Ben A. Oostra; Bernhard Paulweber; Lydia Quaye; Aila Rissanen; Michael Roden; Ida Surakka; Ana M. Valdes; Katriina Vuolteenaho; Barbara Thorand; Ko Willems van Dijk; Jaakko Kaprio; Tim D. Spector; P. Eline Slagboom; Nilesh J. Samani; Florian Kronenberg; Cornelia M. van Duijn; Karl Heinz Ladwig

doi:10.1007/s10654-014-9940-1

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants.

Linda Broer^*, Julia Raschenberger, Joris Deelen, Massimo Mangino, Veryan Codd, Kirsi H. Pietiläinen, Eva Albrecht, Najaf Amin, Marian Beekman, Anton J M de Craen, Christian Gieger, Margot Haun, Peter Henneman, Christian Herder, Iiris Hovatta, Annika Laser, Lyudmyla Kedenko, Wolfgang Koenig, Barbara Kollerits, Eeva MoilanenBen A. Oostra, Bernhard Paulweber, Lydia Quaye, Aila Rissanen, Michael Roden, Ida Surakka, Ana M. Valdes, Katriina Vuolteenaho, Barbara Thorand, Ko Willems van Dijk, Jaakko Kaprio, Tim D. Spector, P. Eline Slagboom, Nilesh J. Samani, Florian Kronenberg, Cornelia M. van Duijn, Karl Heinz Ladwig

^*Corresponding author for this work

Twin Research & Genetic Epidemiology

Erasmus University Medical Center

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Oxidative stress and inflammation are major contributors to accelerated age-related relative telomere length (RTL) shortening. Both conditions are strongly linked to leptin and adiponectin, the most prominent adipocyte-derived protein hormones. As high leptin levels and low levels of adiponectin have been implicated in inflammation, one expects adiponectin to be positively associated with RTL while leptin should be negatively associated. Within the ENGAGE consortium, we investigated the association of RTL with adiponectin and leptin in seven independent cohorts with a total of 11,448 participants. We performed partial correlation analysis on Z-transformed RTL and LN-transformed leptin/adiponectin, adjusting for age and sex. In extended models we adjusted for body mass index (BMI) and C-reactive protein (CRP). Adiponectin showed a borderline significant association with RTL. This appeared to be determined by a single study and when the outlier study was removed, this association disappeared. The association between RTL and leptin was highly significant (r = -0.05; p = 1.81 × 10(-7)). Additional adjustment for BMI or CRP did not change the results. Sex-stratified analysis revealed no difference between men and women. Our study suggests that high leptin levels are associated with short RTL.

Original language	English
Pages (from-to)	629-638
Number of pages	10
Journal	EUROPEAN JOURNAL OF EPIDEMIOLOGY
Volume	29
Issue number	9
DOIs	https://doi.org/10.1007/s10654-014-9940-1
Publication status	Published - 1 Sept 2014

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Broer, L., Raschenberger, J., Deelen, J., Mangino, M., Codd, V., Pietiläinen, K. H., Albrecht, E., Amin, N., Beekman, M., de Craen, A. J. M., Gieger, C., Haun, M., Henneman, P., Herder, C., Hovatta, I., Laser, A., Kedenko, L., Koenig, W., Kollerits, B., ... Ladwig, K. H. (2014). Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 29(9), 629-638. https://doi.org/10.1007/s10654-014-9940-1

@article{cdcaa347cb554af7abe0dd6488e96212,

title = "Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants.",

abstract = "Oxidative stress and inflammation are major contributors to accelerated age-related relative telomere length (RTL) shortening. Both conditions are strongly linked to leptin and adiponectin, the most prominent adipocyte-derived protein hormones. As high leptin levels and low levels of adiponectin have been implicated in inflammation, one expects adiponectin to be positively associated with RTL while leptin should be negatively associated. Within the ENGAGE consortium, we investigated the association of RTL with adiponectin and leptin in seven independent cohorts with a total of 11,448 participants. We performed partial correlation analysis on Z-transformed RTL and LN-transformed leptin/adiponectin, adjusting for age and sex. In extended models we adjusted for body mass index (BMI) and C-reactive protein (CRP). Adiponectin showed a borderline significant association with RTL. This appeared to be determined by a single study and when the outlier study was removed, this association disappeared. The association between RTL and leptin was highly significant (r = -0.05; p = 1.81 × 10(-7)). Additional adjustment for BMI or CRP did not change the results. Sex-stratified analysis revealed no difference between men and women. Our study suggests that high leptin levels are associated with short RTL.",

author = "Linda Broer and Julia Raschenberger and Joris Deelen and Massimo Mangino and Veryan Codd and Pietil{\"a}inen, {Kirsi H.} and Eva Albrecht and Najaf Amin and Marian Beekman and {de Craen}, {Anton J M} and Christian Gieger and Margot Haun and Peter Henneman and Christian Herder and Iiris Hovatta and Annika Laser and Lyudmyla Kedenko and Wolfgang Koenig and Barbara Kollerits and Eeva Moilanen and Oostra, {Ben A.} and Bernhard Paulweber and Lydia Quaye and Aila Rissanen and Michael Roden and Ida Surakka and Valdes, {Ana M.} and Katriina Vuolteenaho and Barbara Thorand and {van Dijk}, {Ko Willems} and Jaakko Kaprio and Spector, {Tim D.} and Slagboom, {P. Eline} and Samani, {Nilesh J.} and Florian Kronenberg and {van Duijn}, {Cornelia M.} and Ladwig, {Karl Heinz}",

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doi = "10.1007/s10654-014-9940-1",

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Broer, L, Raschenberger, J, Deelen, J, Mangino, M, Codd, V, Pietiläinen, KH, Albrecht, E, Amin, N, Beekman, M, de Craen, AJM, Gieger, C, Haun, M, Henneman, P, Herder, C, Hovatta, I, Laser, A, Kedenko, L, Koenig, W, Kollerits, B, Moilanen, E, Oostra, BA, Paulweber, B, Quaye, L, Rissanen, A, Roden, M, Surakka, I, Valdes, AM, Vuolteenaho, K, Thorand, B, van Dijk, KW, Kaprio, J, Spector, TD, Slagboom, PE, Samani, NJ, Kronenberg, F, van Duijn, CM & Ladwig, KH 2014, 'Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants.', EUROPEAN JOURNAL OF EPIDEMIOLOGY, vol. 29, no. 9, pp. 629-638. https://doi.org/10.1007/s10654-014-9940-1

TY - JOUR

T1 - Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants.

AU - Broer, Linda

AU - Raschenberger, Julia

AU - Deelen, Joris

AU - Mangino, Massimo

AU - Codd, Veryan

AU - Pietiläinen, Kirsi H.

AU - Albrecht, Eva

AU - Amin, Najaf

AU - Beekman, Marian

AU - de Craen, Anton J M

AU - Gieger, Christian

AU - Haun, Margot

AU - Henneman, Peter

AU - Herder, Christian

AU - Hovatta, Iiris

AU - Laser, Annika

AU - Kedenko, Lyudmyla

AU - Koenig, Wolfgang

AU - Kollerits, Barbara

AU - Moilanen, Eeva

AU - Oostra, Ben A.

AU - Paulweber, Bernhard

AU - Quaye, Lydia

AU - Rissanen, Aila

AU - Roden, Michael

AU - Surakka, Ida

AU - Valdes, Ana M.

AU - Vuolteenaho, Katriina

AU - Thorand, Barbara

AU - van Dijk, Ko Willems

AU - Kaprio, Jaakko

AU - Spector, Tim D.

AU - Slagboom, P. Eline

AU - Samani, Nilesh J.

AU - Kronenberg, Florian

AU - van Duijn, Cornelia M.

AU - Ladwig, Karl Heinz

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Oxidative stress and inflammation are major contributors to accelerated age-related relative telomere length (RTL) shortening. Both conditions are strongly linked to leptin and adiponectin, the most prominent adipocyte-derived protein hormones. As high leptin levels and low levels of adiponectin have been implicated in inflammation, one expects adiponectin to be positively associated with RTL while leptin should be negatively associated. Within the ENGAGE consortium, we investigated the association of RTL with adiponectin and leptin in seven independent cohorts with a total of 11,448 participants. We performed partial correlation analysis on Z-transformed RTL and LN-transformed leptin/adiponectin, adjusting for age and sex. In extended models we adjusted for body mass index (BMI) and C-reactive protein (CRP). Adiponectin showed a borderline significant association with RTL. This appeared to be determined by a single study and when the outlier study was removed, this association disappeared. The association between RTL and leptin was highly significant (r = -0.05; p = 1.81 × 10(-7)). Additional adjustment for BMI or CRP did not change the results. Sex-stratified analysis revealed no difference between men and women. Our study suggests that high leptin levels are associated with short RTL.

AB - Oxidative stress and inflammation are major contributors to accelerated age-related relative telomere length (RTL) shortening. Both conditions are strongly linked to leptin and adiponectin, the most prominent adipocyte-derived protein hormones. As high leptin levels and low levels of adiponectin have been implicated in inflammation, one expects adiponectin to be positively associated with RTL while leptin should be negatively associated. Within the ENGAGE consortium, we investigated the association of RTL with adiponectin and leptin in seven independent cohorts with a total of 11,448 participants. We performed partial correlation analysis on Z-transformed RTL and LN-transformed leptin/adiponectin, adjusting for age and sex. In extended models we adjusted for body mass index (BMI) and C-reactive protein (CRP). Adiponectin showed a borderline significant association with RTL. This appeared to be determined by a single study and when the outlier study was removed, this association disappeared. The association between RTL and leptin was highly significant (r = -0.05; p = 1.81 × 10(-7)). Additional adjustment for BMI or CRP did not change the results. Sex-stratified analysis revealed no difference between men and women. Our study suggests that high leptin levels are associated with short RTL.

UR - http://www.scopus.com/inward/record.url?scp=84908468733&partnerID=8YFLogxK

U2 - 10.1007/s10654-014-9940-1

DO - 10.1007/s10654-014-9940-1

M3 - Article

C2 - 25064619

AN - SCOPUS:84908468733

SN - 0393-2990

VL - 29

SP - 629

EP - 638

JO - EUROPEAN JOURNAL OF EPIDEMIOLOGY

JF - EUROPEAN JOURNAL OF EPIDEMIOLOGY

IS - 9

ER -

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants.

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