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Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression

Research output: Contribution to journalArticle

Lina Quteineh, Martin Preisig, Margarita Rivera, Yuri Milaneschi, Enrique Castelao, Mehdi Gholam-Rezaee, Frederik Vandenberghe, Nuria Saigi-Morgui, Aurélie Delacrétaz, Jean-René Cardinaux, Gonneke Willemsen, Dorret I. Boomsma, Brenda W.J.H. Penninx, Ana Ching-López, Philippe Conus, Chin B. Eap

Original languageEnglish
JournalJournal of Affective Disorders
Early online date10 Mar 2016
Accepted/In press9 Mar 2016
E-pub ahead of print10 Mar 2016


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    Uploaded date:11 Mar 2016

    Version:Accepted author manuscript

    Licence:CC BY-NC-ND

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AbstractBackground Psychiatric disorders have been hypothesized to share common etiological pathways with obesity, suggesting related neurobiological bases. We aimed to examine whether CRTC1 polymorphisms were associated with major depressive disorder (MDD) and to test the association of these polymorphisms with obesity markers in several large case-control samples with MDD. Methods The association between CRTC1 polymorphisms and MDD was investigated in three case-control samples with MDD (PsyCoLaus n1=3,362, Radiant n2=3,148 and NESDA/NTR n3=4,663). The effect of CRTC1 polymorphisms on obesity markers was then explored. Results CRTC1 polymorphisms were not associated with MDD in the three samples. CRTC1 rs6510997C>T was significantly associated with fat mass in the PsyCoLaus study. In fact, a protective effect of this polymorphism was found in MDD cases (n=1,434, β=−1.32%, 95% CI −2.07 to −0.57, P<0.001), but not in controls. In the Radiant study, CRTC1 polymorphisms were associated with BMI, exclusively in individuals with MDD (n=2,138, β=−0.75 kg/m2, 95% CI -1.30 to -0.21, p=0.007), while no association with BMI was found in the NESDA/NTR study. Limitations Estimated fat mass using bioimpedance that capture more accurately adiposity was only present in the PsyCoLaus sample. Conclusions CRTC1 polymorphisms seem to play a role with obesity markers in individuals with MDD rather than non-depressive individuals. Therefore, the weak association previously reported in the population-based samples was driven by cases diagnosed with lifetime MDD. However, CRTC1 seems not to be implicated directly in the development of psychiatric diseases. Keywords

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