Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients

C. Guindalini; S. Scivoletto; R. G. M. Ferreira; G. Breen; M. Zilberman; M. A. Peluso; M. Zatz

doi:10.1176/appi.ajp.162.5.1005

Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients

C. Guindalini, S. Scivoletto, R. G. M. Ferreira, G. Breen, M. Zilberman, M. A. Peluso, M. Zatz

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: The authors evaluated the association of three functional promoter polymorphisms of the ADH4 gene with alcohol dependence. Method: DNA from 92 alcohol-dependent patients and 92 healthy comparison subjects was genotyped for all three polymorphisms. Results: Variants at the - 75 base-pair ( bp) ( C allele) and - 159 bp ( A allele) positions were associated with alcohol dependence. Individuals with haplotypes carrying both risk alleles showed an odds ratio of 2.9. Conclusions: These preliminary results suggest that ADH4 may play a role in the etiology of alcohol dependence. The association requires further study and replication but is functionally plausible and has a large effect size

Original language	English
Pages (from-to)	1005 - 1007
Number of pages	3
Journal	The American Journal of Psychiatry
Volume	162
Issue number	5
DOIs	https://doi.org/10.1176/appi.ajp.162.5.1005
Publication status	Published - May 2005

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title = "Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients",

abstract = "Objective: The authors evaluated the association of three functional promoter polymorphisms of the ADH4 gene with alcohol dependence. Method: DNA from 92 alcohol-dependent patients and 92 healthy comparison subjects was genotyped for all three polymorphisms. Results: Variants at the - 75 base-pair ( bp) ( C allele) and - 159 bp ( A allele) positions were associated with alcohol dependence. Individuals with haplotypes carrying both risk alleles showed an odds ratio of 2.9. Conclusions: These preliminary results suggest that ADH4 may play a role in the etiology of alcohol dependence. The association requires further study and replication but is functionally plausible and has a large effect size",

author = "C. Guindalini and S. Scivoletto and Ferreira, {R. G. M.} and G. Breen and M. Zilberman and Peluso, {M. A.} and M. Zatz",

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T1 - Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients

AU - Guindalini, C.

AU - Scivoletto, S.

AU - Ferreira, R. G. M.

AU - Breen, G.

AU - Zilberman, M.

AU - Peluso, M. A.

AU - Zatz, M.

N1 - Times Cited: 31

PY - 2005/5

Y1 - 2005/5

N2 - Objective: The authors evaluated the association of three functional promoter polymorphisms of the ADH4 gene with alcohol dependence. Method: DNA from 92 alcohol-dependent patients and 92 healthy comparison subjects was genotyped for all three polymorphisms. Results: Variants at the - 75 base-pair ( bp) ( C allele) and - 159 bp ( A allele) positions were associated with alcohol dependence. Individuals with haplotypes carrying both risk alleles showed an odds ratio of 2.9. Conclusions: These preliminary results suggest that ADH4 may play a role in the etiology of alcohol dependence. The association requires further study and replication but is functionally plausible and has a large effect size

AB - Objective: The authors evaluated the association of three functional promoter polymorphisms of the ADH4 gene with alcohol dependence. Method: DNA from 92 alcohol-dependent patients and 92 healthy comparison subjects was genotyped for all three polymorphisms. Results: Variants at the - 75 base-pair ( bp) ( C allele) and - 159 bp ( A allele) positions were associated with alcohol dependence. Individuals with haplotypes carrying both risk alleles showed an odds ratio of 2.9. Conclusions: These preliminary results suggest that ADH4 may play a role in the etiology of alcohol dependence. The association requires further study and replication but is functionally plausible and has a large effect size

U2 - 10.1176/appi.ajp.162.5.1005

DO - 10.1176/appi.ajp.162.5.1005

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EP - 1007

JO - The American Journal of Psychiatry

JF - The American Journal of Psychiatry

IS - 5

ER -

Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients

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