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Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population

Research output: Contribution to journalArticle

Wenlong C Chen, Hannah Bye, Marco Matejcic, Ariella Amar, Dhiren Govender, Yee Wen Khew, Victoria Beynon, Robyn Kerr, Elvira Singh, Natalie J Prescott, Cathryn M Lewis, Chantal Babb de Villiers, M Iqbal Parker, Christopher G Mathew

Original languageEnglish
Article numberbgz026
Pages (from-to)513-520
Number of pages8
JournalCarcinogenesis
Volume40
Issue number4
Early online date12 Feb 2019
DOIs
Accepted/In press7 Feb 2019
E-pub ahead of print12 Feb 2019
PublishedApr 2019

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Abstract

Oesophageal squamous cell carcinoma (OSCC) has a high incidence in southern Africa and a poor prognosis. Limited information is available on the contribution of genetic variants in susceptibility to OSCC in this region. However, recent genome-wide association studies have identified multiple susceptibility loci in Asian and European populations. In this study, we investigated genetic variants from seven OSCC risk loci identified in non-African populations for association with OSCC in the South African Black population. We performed association studies in a total of 1471 cases and 1791 controls from two study sample groups, which included 591 cases and 852 controls from the Western Cape and 880 cases and 939 controls from the Johannesburg region in the Gauteng province. Thereafter, we performed a meta-analysis for 11 variants which had been genotyped in both studies. A single nucleotide polymorphism in the CHEK2 gene, rs1033667, was significantly associated with OSCC [P = 0.002; odds ratio (OR) = 1.176; 95% confidence interval (CI): 1.06-1.30]. However, single nucleotide polymorphisms in the CASP8/ALS2CR12, TMEM173, PLCE1, ALDH2, ATP1B2/TP53 and RUNX1 loci were not associated with the disease (P > 0.05). The lack of association of six of these loci with OSCC in South African populations may reflect different genetic risk factors in non-African and African populations or differences in the genetic architecture of African genomes. The association at CHEK2, a gene with key roles in cell cycle regulation and DNA repair, in an African population provides further support for the contribution of common genetic variants at this locus to the risk of oesophageal cancer.

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