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Association of migraine aura with patent foramen ovale and atrial septal aneurysms

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Association of migraine aura with patent foramen ovale and atrial septal aneurysms. / Chambers, John; Seed, Paul T.; Ridsdale, Leone.

In: International Journal of Cardiology, Vol. 168, No. 4, 09.10.2013, p. 3949-3953.

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Harvard

Chambers, J, Seed, PT & Ridsdale, L 2013, 'Association of migraine aura with patent foramen ovale and atrial septal aneurysms', International Journal of Cardiology, vol. 168, no. 4, pp. 3949-3953. https://doi.org/10.1016/j.ijcard.2013.06.054

APA

Chambers, J., Seed, P. T., & Ridsdale, L. (2013). Association of migraine aura with patent foramen ovale and atrial septal aneurysms. International Journal of Cardiology, 168(4), 3949-3953. https://doi.org/10.1016/j.ijcard.2013.06.054

Vancouver

Chambers J, Seed PT, Ridsdale L. Association of migraine aura with patent foramen ovale and atrial septal aneurysms. International Journal of Cardiology. 2013 Oct 9;168(4):3949-3953. https://doi.org/10.1016/j.ijcard.2013.06.054

Author

Chambers, John ; Seed, Paul T. ; Ridsdale, Leone. / Association of migraine aura with patent foramen ovale and atrial septal aneurysms. In: International Journal of Cardiology. 2013 ; Vol. 168, No. 4. pp. 3949-3953.

Bibtex Download

@article{0eb868e7cfdf4809af976daec70475f2,
title = "Association of migraine aura with patent foramen ovale and atrial septal aneurysms",
abstract = "Background: The relationship between migrainous aura and patent foramen ovale (PFO) remains uncertain.Methods: We performed ‘bubble’ contrast transthoracic echocardiography on 80 migraineurs with 4–15 headache days per calendar month, mean age 45 (75{\%} female) with mean 9.4 headache days. A large PFO was defined by passage of an uncountable bolus of bubbles or complete opacification of the left-heart in ≤3 cycles, while a moderate PFO was defined by passage of ≥20 bubbles but not sufficient to form a bolus or opacify the whole of the left heart.Results: There was a moderate or large PFO in 28 (35{\%}; 95{\%} CI 24–46{\%}). There were atrial septal aneurysms in 11 (15{\%}) and the relationship with PFO was moderately strong (spearman rank correlation 0.493, CI 0.308 to0.643; p b 0.0001). Seven (9{\%}) had a valve abnormality and one had a closure device for an atrial septal defect. Aura were reported in 31 (39{\%}) and in these the PFO was large in 9 (29{\%}) compared with 8 (16{\%}; p = 0.143) without aura. There was no relationship between the size of the PFO and the number of headachedays (difference between no PFO and large PFO=−0.6 days; 95{\%} CI –2.6 to+1.4; p-value for any differencebetween groups = 0.316).Conclusions: The prevalence of moderate or large patent foramen ovale was 35{\%} and was not associated with the presence of aura or the frequency of the headache.",
keywords = "Atrial septal aneurysm, Migraine, Patent foramen ovale",
author = "John Chambers and Seed, {Paul T.} and Leone Ridsdale",
year = "2013",
month = "10",
day = "9",
doi = "10.1016/j.ijcard.2013.06.054",
language = "English",
volume = "168",
pages = "3949--3953",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Association of migraine aura with patent foramen ovale and atrial septal aneurysms

AU - Chambers, John

AU - Seed, Paul T.

AU - Ridsdale, Leone

PY - 2013/10/9

Y1 - 2013/10/9

N2 - Background: The relationship between migrainous aura and patent foramen ovale (PFO) remains uncertain.Methods: We performed ‘bubble’ contrast transthoracic echocardiography on 80 migraineurs with 4–15 headache days per calendar month, mean age 45 (75% female) with mean 9.4 headache days. A large PFO was defined by passage of an uncountable bolus of bubbles or complete opacification of the left-heart in ≤3 cycles, while a moderate PFO was defined by passage of ≥20 bubbles but not sufficient to form a bolus or opacify the whole of the left heart.Results: There was a moderate or large PFO in 28 (35%; 95% CI 24–46%). There were atrial septal aneurysms in 11 (15%) and the relationship with PFO was moderately strong (spearman rank correlation 0.493, CI 0.308 to0.643; p b 0.0001). Seven (9%) had a valve abnormality and one had a closure device for an atrial septal defect. Aura were reported in 31 (39%) and in these the PFO was large in 9 (29%) compared with 8 (16%; p = 0.143) without aura. There was no relationship between the size of the PFO and the number of headachedays (difference between no PFO and large PFO=−0.6 days; 95% CI –2.6 to+1.4; p-value for any differencebetween groups = 0.316).Conclusions: The prevalence of moderate or large patent foramen ovale was 35% and was not associated with the presence of aura or the frequency of the headache.

AB - Background: The relationship between migrainous aura and patent foramen ovale (PFO) remains uncertain.Methods: We performed ‘bubble’ contrast transthoracic echocardiography on 80 migraineurs with 4–15 headache days per calendar month, mean age 45 (75% female) with mean 9.4 headache days. A large PFO was defined by passage of an uncountable bolus of bubbles or complete opacification of the left-heart in ≤3 cycles, while a moderate PFO was defined by passage of ≥20 bubbles but not sufficient to form a bolus or opacify the whole of the left heart.Results: There was a moderate or large PFO in 28 (35%; 95% CI 24–46%). There were atrial septal aneurysms in 11 (15%) and the relationship with PFO was moderately strong (spearman rank correlation 0.493, CI 0.308 to0.643; p b 0.0001). Seven (9%) had a valve abnormality and one had a closure device for an atrial septal defect. Aura were reported in 31 (39%) and in these the PFO was large in 9 (29%) compared with 8 (16%; p = 0.143) without aura. There was no relationship between the size of the PFO and the number of headachedays (difference between no PFO and large PFO=−0.6 days; 95% CI –2.6 to+1.4; p-value for any differencebetween groups = 0.316).Conclusions: The prevalence of moderate or large patent foramen ovale was 35% and was not associated with the presence of aura or the frequency of the headache.

KW - Atrial septal aneurysm

KW - Migraine

KW - Patent foramen ovale

UR - http://www.scopus.com/inward/record.url?scp=84886292114&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2013.06.054

DO - 10.1016/j.ijcard.2013.06.054

M3 - Article

C2 - 23890906

AN - SCOPUS:84886292114

VL - 168

SP - 3949

EP - 3953

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 4

ER -

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