Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus

Deborah S Cunninghame Graham; David L Morris; Tushar R Bhangale; Lindsey A Criswell; Ann-Christine Syvänen; Lars Rönnblom; Timothy W Behrens; Robert R Graham; Timothy J Vyse

doi:10.1371/journal.pgen.1002341

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus

Deborah S Cunninghame Graham, David L Morris, Tushar R Bhangale, Lindsey A Criswell, Ann-Christine Syvänen, Lars Rönnblom, Timothy W Behrens, Robert R Graham, Timothy J Vyse

Medical & Molecular Genetics

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Abstract

Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a range of auto-antibodies and a diverse set of clinical phenotypes. Currently, ~8% of the genetic contribution to SLE in Europeans is known, following publication of several moderate-sized genome-wide (GW) association studies, which identified loci with a strong effect (OR>1.3). In order to identify additional genes contributing to SLE susceptibility, we conducted a replication study in a UK dataset (870 cases, 5,551 controls) of 23 variants that showed moderate-risk for lupus in previous studies. Association analysis in the UK dataset and subsequent meta-analysis with the published data identified five SLE susceptibility genes reaching genome-wide levels of significance (P(comb)

Original language	English
Article number	e1002341
Journal	PL o S Genetics
Volume	7
Issue number	10
DOIs	https://doi.org/10.1371/journal.pgen.1002341
Publication status	Published - Oct 2011

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title = "Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus",

abstract = "Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a range of auto-antibodies and a diverse set of clinical phenotypes. Currently, ~8% of the genetic contribution to SLE in Europeans is known, following publication of several moderate-sized genome-wide (GW) association studies, which identified loci with a strong effect (OR>1.3). In order to identify additional genes contributing to SLE susceptibility, we conducted a replication study in a UK dataset (870 cases, 5,551 controls) of 23 variants that showed moderate-risk for lupus in previous studies. Association analysis in the UK dataset and subsequent meta-analysis with the published data identified five SLE susceptibility genes reaching genome-wide levels of significance (P(comb)",

author = "{Cunninghame Graham}, {Deborah S} and Morris, {David L} and Bhangale, {Tushar R} and Criswell, {Lindsey A} and Ann-Christine Syv{\"a}nen and Lars R{\"o}nnblom and Behrens, {Timothy W} and Graham, {Robert R} and Vyse, {Timothy J}",

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AU - Cunninghame Graham, Deborah S

AU - Morris, David L

AU - Bhangale, Tushar R

AU - Criswell, Lindsey A

AU - Syvänen, Ann-Christine

AU - Rönnblom, Lars

AU - Behrens, Timothy W

AU - Graham, Robert R

AU - Vyse, Timothy J

PY - 2011/10

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N2 - Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a range of auto-antibodies and a diverse set of clinical phenotypes. Currently, ~8% of the genetic contribution to SLE in Europeans is known, following publication of several moderate-sized genome-wide (GW) association studies, which identified loci with a strong effect (OR>1.3). In order to identify additional genes contributing to SLE susceptibility, we conducted a replication study in a UK dataset (870 cases, 5,551 controls) of 23 variants that showed moderate-risk for lupus in previous studies. Association analysis in the UK dataset and subsequent meta-analysis with the published data identified five SLE susceptibility genes reaching genome-wide levels of significance (P(comb)

AB - Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a range of auto-antibodies and a diverse set of clinical phenotypes. Currently, ~8% of the genetic contribution to SLE in Europeans is known, following publication of several moderate-sized genome-wide (GW) association studies, which identified loci with a strong effect (OR>1.3). In order to identify additional genes contributing to SLE susceptibility, we conducted a replication study in a UK dataset (870 cases, 5,551 controls) of 23 variants that showed moderate-risk for lupus in previous studies. Association analysis in the UK dataset and subsequent meta-analysis with the published data identified five SLE susceptibility genes reaching genome-wide levels of significance (P(comb)

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DO - 10.1371/journal.pgen.1002341

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SN - 1553-7404

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JO - PL o S Genetics

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IS - 10

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ER -

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus

Abstract

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