Association of pertussis and measles infections and immunizations with asthma and allergic sensitization in ISAAC Phase Two

TY - JOUR

T1 - Association of pertussis and measles infections and immunizations with asthma and allergic sensitization in ISAAC Phase Two

AU - Nagel, Gabriele

AU - Weinmayr, Gudrun

AU - Flohr, Carsten

AU - Kleiner, Andrea

AU - Strachan, David P.

AU - ISAAC Phase Two Study Grp

PY - 2012/12

Y1 - 2012/12

N2 - Background: Pertussis and measles infection as well as vaccination have been suspected as possible mediating factors of allergic disease in childhood. Methods: Between 1995 and 2005 cross-sectional studies were performed in 29 centers in 21 countries. Parental questionnaires were used to collect information on allergic diseases and exposures. We analyzed data from 54,943 randomly selected schoolchildren aged 8-12 yr. A subgroup of 31,759 children was also skin prick tested (SPT) to common environmental allergens. Combined odds ratios were calculated by random effect models for meta-analysis. Results: Pertussis and measles vaccination were not significantly associated with any of the allergy outcomes or SPT positivity. However, pertussis infection was associated with wheeze (ORad 1.68; 95% CI 1.441.97) and rhinoconjunctivitis (ORad 1.63; 95% 1.332.00). Pertussis infection was also significantly associated with a higher prevalence of reported eczema during the past year in non-affluent countries. Measles infection was associated with a higher prevalence of wheeze (ORad 1.26; 95% 1.101.43) and reported eczema (ORad 1.22; 95% 1.081.39). No association with SPT positivity was found, suggesting that these associations are unlikely to be mediated by an allergic component. Conclusions: Associations of pertussis and measles infection with symptoms of asthma, rhinoconjunctivitis and eczema were found in both affluent and non-affluent countries and are unlikely to be mediated by IgE.

AB - Background: Pertussis and measles infection as well as vaccination have been suspected as possible mediating factors of allergic disease in childhood. Methods: Between 1995 and 2005 cross-sectional studies were performed in 29 centers in 21 countries. Parental questionnaires were used to collect information on allergic diseases and exposures. We analyzed data from 54,943 randomly selected schoolchildren aged 8-12 yr. A subgroup of 31,759 children was also skin prick tested (SPT) to common environmental allergens. Combined odds ratios were calculated by random effect models for meta-analysis. Results: Pertussis and measles vaccination were not significantly associated with any of the allergy outcomes or SPT positivity. However, pertussis infection was associated with wheeze (ORad 1.68; 95% CI 1.441.97) and rhinoconjunctivitis (ORad 1.63; 95% 1.332.00). Pertussis infection was also significantly associated with a higher prevalence of reported eczema during the past year in non-affluent countries. Measles infection was associated with a higher prevalence of wheeze (ORad 1.26; 95% 1.101.43) and reported eczema (ORad 1.22; 95% 1.081.39). No association with SPT positivity was found, suggesting that these associations are unlikely to be mediated by an allergic component. Conclusions: Associations of pertussis and measles infection with symptoms of asthma, rhinoconjunctivitis and eczema were found in both affluent and non-affluent countries and are unlikely to be mediated by IgE.

KW - RISK

KW - DISEASES

KW - HAY-FEVER

KW - CHILDREN

KW - atopy

KW - bronchial hyperreactivity

KW - pertussis

KW - International Study of Asthma and Allergies in Childhood

KW - CHILDHOOD ISAAC

KW - measles

KW - FAMILY-SIZE

KW - VACCINATION

KW - asthma

KW - SYMPTOMS

KW - PREVALENCE

KW - ATOPIC SENSITIZATION

U2 - 10.1111/pai.12007

DO - 10.1111/pai.12007

M3 - Article

SN - 0905-6157

VL - 23

SP - 736

EP - 745

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

IS - 8

M1 - N/A

ER -