Association study of dysbindin gene with clinical and outcome measures in a representative cohort of Italian schizophrenic patients

TY - JOUR

T1 - Association study of dysbindin gene with clinical and outcome measures in a representative cohort of Italian schizophrenic patients

AU - Tosato, S

AU - Ruggeri, M

AU - Bonetto, C

AU - Bertani, M

AU - Marrella, G

AU - Lasalvia, A

AU - Cristofalo, D

AU - Aprili, G

AU - Tansella, M

AU - Dazzan, P

AU - DiForti, M

AU - Murray, R M

AU - Collier, D A

PY - 2007/7/5

Y1 - 2007/7/5

N2 - There is evidence suggesting that Dysbindin (DTNBP1) is a susceptibility gene for schizophrenia in Caucasian, Chinese, and Japanese populations. We sought to determine if dysbindin was associated with schizophrenia and its symptoms in a representative group of schizophrenic patients from a Community-Based Mental Health Service (CMHS) in Verona, Italy. A prevalence cohort of schizophrenic patients (n = 141) was assessed at baseline and then 3 and 6 years later. Eighty patients and 106 healthy controls were genotyped for polymorphisms in dysbindin. We tested if diagnosis, clinical symptoms as measured by the Brief Psychiatric Rating Scale (BPRS), and functioning as measured by the Global Assessment of Functioning Scale (GAF), were associated with the presence of certain dysbindin polymorphisms. Finally, using the longitudinal clinical data, we tested if patients carrying dysbindin high-risk haplotypes had a more unfavorable longitudinal clinical outcome. A trend towards statistical association (P = 0.058) between schizophrenia and rs2619538 was found. Using GENECOUNTING software, we found that rs2619538P1583 (P=0.048), P1320-PI757 (P=0.034), and rs2619538-P1583-P1578 (P=0.040) haplotypes occurred more often in cases compared to controls before correction for multiple testing. rhe rs2619538-P1583 haplotype was more likely to be transmitted to subjects with more severe and persistent psychopathology. These preliminary results are compatible with the viewthat DTNBP1 is a susceptibility factor for schizophrenia, and is associated with worse psychopathology. (c) 2007 Wiley-Liss,

AB - There is evidence suggesting that Dysbindin (DTNBP1) is a susceptibility gene for schizophrenia in Caucasian, Chinese, and Japanese populations. We sought to determine if dysbindin was associated with schizophrenia and its symptoms in a representative group of schizophrenic patients from a Community-Based Mental Health Service (CMHS) in Verona, Italy. A prevalence cohort of schizophrenic patients (n = 141) was assessed at baseline and then 3 and 6 years later. Eighty patients and 106 healthy controls were genotyped for polymorphisms in dysbindin. We tested if diagnosis, clinical symptoms as measured by the Brief Psychiatric Rating Scale (BPRS), and functioning as measured by the Global Assessment of Functioning Scale (GAF), were associated with the presence of certain dysbindin polymorphisms. Finally, using the longitudinal clinical data, we tested if patients carrying dysbindin high-risk haplotypes had a more unfavorable longitudinal clinical outcome. A trend towards statistical association (P = 0.058) between schizophrenia and rs2619538 was found. Using GENECOUNTING software, we found that rs2619538P1583 (P=0.048), P1320-PI757 (P=0.034), and rs2619538-P1583-P1578 (P=0.040) haplotypes occurred more often in cases compared to controls before correction for multiple testing. rhe rs2619538-P1583 haplotype was more likely to be transmitted to subjects with more severe and persistent psychopathology. These preliminary results are compatible with the viewthat DTNBP1 is a susceptibility factor for schizophrenia, and is associated with worse psychopathology. (c) 2007 Wiley-Liss,

U2 - 10.1002/ajmg.b.30484

DO - 10.1002/ajmg.b.30484

M3 - Article

SN - 1552-485X

VL - 144B

SP - 647

EP - 659

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

IS - 5

ER -