Association Study of the Estrogen Receptor Alpha Gene (ESR1) and Childhood-Onset Mood Disorders

Jonathan Mill; Eniko Kiss; Ildiko Baji; Krisztina Kapornai; Gabriella Daroczy; Agnes Vetro; James Kennedy; Maria Kovacs; Cathy Barr

doi:10.1002/ajmg.b.30751

Association Study of the Estrogen Receptor Alpha Gene (ESR1) and Childhood-Onset Mood Disorders

Jonathan Mill, Eniko Kiss, Ildiko Baji, Krisztina Kapornai, Gabriella Daroczy, Agnes Vetro, James Kennedy, Maria Kovacs, Cathy Barr

Social Genetic & Developmental Psychiatry

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Depressive disorders are heterogeneous psychiatric disorders involving deficits in cognitive, psychomotor, and emotional processing. Depressive disorders have a significant genetic component, with severe, recurrent and early-onset forms demonstrating elevated heritability. In this study we genotyped eleven single nucleotide polymorphisms (SNPs) spanning the estrogen receptor alpha gene (ESR1) in a large family-based childhood-onset mood disorder (COMD) sample. None of the individual SNP or global haplotype analyses was significant in the entire COMD sample, but haplotype analysis of three SNPs in strong linkage disequilibrium (rs746432, rs2077647, and rs532010) uncovered an association with COMD, specifically in females. Our data are consistent with previous studies demonstrating a female-specific association between ESR1 and neurobehavioral phenotypes. These results suggest the existence of sex-specific etiological factors in depressive disorders, related to estrogen, with onset in childhood. (C) 2008 Wiley-Liss, Inc.

Original language	English
Pages (from-to)	1323 - 1326
Number of pages	4
Journal	American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Volume	147B
Issue number	7
DOIs	https://doi.org/10.1002/ajmg.b.30751
Publication status	Published - 5 Oct 2008

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title = "Association Study of the Estrogen Receptor Alpha Gene (ESR1) and Childhood-Onset Mood Disorders",

abstract = "Depressive disorders are heterogeneous psychiatric disorders involving deficits in cognitive, psychomotor, and emotional processing. Depressive disorders have a significant genetic component, with severe, recurrent and early-onset forms demonstrating elevated heritability. In this study we genotyped eleven single nucleotide polymorphisms (SNPs) spanning the estrogen receptor alpha gene (ESR1) in a large family-based childhood-onset mood disorder (COMD) sample. None of the individual SNP or global haplotype analyses was significant in the entire COMD sample, but haplotype analysis of three SNPs in strong linkage disequilibrium (rs746432, rs2077647, and rs532010) uncovered an association with COMD, specifically in females. Our data are consistent with previous studies demonstrating a female-specific association between ESR1 and neurobehavioral phenotypes. These results suggest the existence of sex-specific etiological factors in depressive disorders, related to estrogen, with onset in childhood. (C) 2008 Wiley-Liss, Inc.",

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AU - Mill, Jonathan

AU - Kiss, Eniko

AU - Baji, Ildiko

AU - Kapornai, Krisztina

AU - Daroczy, Gabriella

AU - Vetro, Agnes

AU - Kennedy, James

AU - Kovacs, Maria

AU - Barr, Cathy

PY - 2008/10/5

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N2 - Depressive disorders are heterogeneous psychiatric disorders involving deficits in cognitive, psychomotor, and emotional processing. Depressive disorders have a significant genetic component, with severe, recurrent and early-onset forms demonstrating elevated heritability. In this study we genotyped eleven single nucleotide polymorphisms (SNPs) spanning the estrogen receptor alpha gene (ESR1) in a large family-based childhood-onset mood disorder (COMD) sample. None of the individual SNP or global haplotype analyses was significant in the entire COMD sample, but haplotype analysis of three SNPs in strong linkage disequilibrium (rs746432, rs2077647, and rs532010) uncovered an association with COMD, specifically in females. Our data are consistent with previous studies demonstrating a female-specific association between ESR1 and neurobehavioral phenotypes. These results suggest the existence of sex-specific etiological factors in depressive disorders, related to estrogen, with onset in childhood. (C) 2008 Wiley-Liss, Inc.

AB - Depressive disorders are heterogeneous psychiatric disorders involving deficits in cognitive, psychomotor, and emotional processing. Depressive disorders have a significant genetic component, with severe, recurrent and early-onset forms demonstrating elevated heritability. In this study we genotyped eleven single nucleotide polymorphisms (SNPs) spanning the estrogen receptor alpha gene (ESR1) in a large family-based childhood-onset mood disorder (COMD) sample. None of the individual SNP or global haplotype analyses was significant in the entire COMD sample, but haplotype analysis of three SNPs in strong linkage disequilibrium (rs746432, rs2077647, and rs532010) uncovered an association with COMD, specifically in females. Our data are consistent with previous studies demonstrating a female-specific association between ESR1 and neurobehavioral phenotypes. These results suggest the existence of sex-specific etiological factors in depressive disorders, related to estrogen, with onset in childhood. (C) 2008 Wiley-Liss, Inc.

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Association Study of the Estrogen Receptor Alpha Gene (ESR1) and Childhood-Onset Mood Disorders

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