TY - JOUR
T1 - Associations between childhood victimization, inflammatory biomarkers and psychotic phenomena in adolescence: a longitudinal cohort study.
AU - Trotta, Antonella
AU - Arseneault, Louise
AU - Danese, Andrea
AU - Mondelli, Valeria
AU - Rasmussen, Line Jee Hartmann
AU - Fisher, Helen
N1 - Funding Information:
The E-Risk Study is funded by the UK Medical Research Council [G1002190]. Additional support was provided by the National Institute of Child Health and Human Development [HD077482]; the Jacobs Foundation; a National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre (BRC) Early Career Bridging Grant to Antonella Trotta; and a Lundbeck Foundation postdoctoral fellowship [R288-2018-380] to Line J.H. Rasmussen. Louise Arseneault is the Mental Health Leadership Fellow for the UK Economic and Social Research Council (ESRC). Valeria Mondelli is supported by the Medical Research Foundation [MRF-160-0005-ELP-MONDE] and by the NIHR BRC at South London and Maudsley NHS Foundation Trust and King’s College London. Helen L. Fisher was supported by a British Academy Mid-Career Fellowship [MD\170005] and the ESRC Centre for Society and Mental Health at King’s College London [ES/S012567/1]. The views expressed are those of the authors and not necessarily those of the National Health Service, the NIHR, the Department of Health and Social Care, the ESRC or King’s College London.
Funding Information:
We are grateful to the study mothers and fathers, the twins, and the twins' teachers for their participation. Our thanks to Professors Avshalom Caspi and Terrie Moffitt, the founders of the E-Risk study, members of the E-Risk team for their dedication, hard work, and insights, the Nuffield Foundation, the Avielle Foundation, and CACI, Inc. Dr Trotta and Dr Fisher had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Publisher Copyright:
© 2021
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/11
Y1 - 2021/11
N2 - Exposure to victimization in childhood has been linked to the development of psychosis. However, little is known about how childhood victimization is translated into biological risk for psychosis. One possibility is via increased inflammation. This study aimed to investigate the association between childhood victimization, psychotic experiences (PEs) in adolescence and inflammatory markers using data from a general population cohort. Participants were 1,419 British-born children followed from birth to age 18 years as part of the Environmental Risk Longitudinal Twin Study. Childhood victimization was measured prospectively using multiple sources from birth to age 12 years. PEs were assessed during private interviews with participants at age 18 years for the period since age 12. Plasma C-reactive protein (CRP), interleukin-6 (IL-6), and soluble urokinase plasminogen activator receptor (suPAR) levels were measured from plasma samples collected from participants at 18 years. Young people with both PEs and childhood victimization were more likely to belong to a group with elevated suPAR, CRP and IL-6 levels at 18 years of age (OR = 3.34, 95% CI 1.69–6.59, p = 0.001) than those with no childhood victimization and without PEs. However, this association was attenuated when adjusted for other risk factors for elevated inflammation at age 18 (OR = 1.94, 95% CI 0.94–4.04, p = 0.075). In contrast, presence of PEs without childhood victimization was not significantly associated with age-18 inflammatory markers and neither was childhood victimization without PEs (all p's greater than 0.05). The current study highlights that inflammatory dysregulation is mostly present in adolescents reporting PEs who also experienced childhood victimization, though this seemed to be largely due to concurrent inflammation-related risk factors.
AB - Exposure to victimization in childhood has been linked to the development of psychosis. However, little is known about how childhood victimization is translated into biological risk for psychosis. One possibility is via increased inflammation. This study aimed to investigate the association between childhood victimization, psychotic experiences (PEs) in adolescence and inflammatory markers using data from a general population cohort. Participants were 1,419 British-born children followed from birth to age 18 years as part of the Environmental Risk Longitudinal Twin Study. Childhood victimization was measured prospectively using multiple sources from birth to age 12 years. PEs were assessed during private interviews with participants at age 18 years for the period since age 12. Plasma C-reactive protein (CRP), interleukin-6 (IL-6), and soluble urokinase plasminogen activator receptor (suPAR) levels were measured from plasma samples collected from participants at 18 years. Young people with both PEs and childhood victimization were more likely to belong to a group with elevated suPAR, CRP and IL-6 levels at 18 years of age (OR = 3.34, 95% CI 1.69–6.59, p = 0.001) than those with no childhood victimization and without PEs. However, this association was attenuated when adjusted for other risk factors for elevated inflammation at age 18 (OR = 1.94, 95% CI 0.94–4.04, p = 0.075). In contrast, presence of PEs without childhood victimization was not significantly associated with age-18 inflammatory markers and neither was childhood victimization without PEs (all p's greater than 0.05). The current study highlights that inflammatory dysregulation is mostly present in adolescents reporting PEs who also experienced childhood victimization, though this seemed to be largely due to concurrent inflammation-related risk factors.
UR - http://www.scopus.com/inward/record.url?scp=85112810416&partnerID=8YFLogxK
U2 - 10.1016/j.bbi.2021.08.209
DO - 10.1016/j.bbi.2021.08.209
M3 - Article
SN - 0889-1591
VL - 98
SP - 74
EP - 85
JO - Brain Behavior and Immunity
JF - Brain Behavior and Immunity
ER -