Associations between children’s family environment, spontaneous brain oscillations, and emotional and behavioral problems

TY - JOUR

T1 - Associations between children’s family environment, spontaneous brain oscillations, and emotional and behavioral problems

AU - Sato, João Ricardo

AU - Biazoli, Claudinei Eduardo

AU - Salum, Giovanni Abrahão

AU - Gadelha, Ary

AU - Crossley, Nicolas

AU - Vieira, Gilson

AU - Zugman, André

AU - Picon, Felipe Almeida

AU - Pan, Pedro Mario

AU - Hoexter, Marcelo Queiroz

AU - Amaro, Edson

AU - Anés, Mauricio

AU - Moura, Luciana Monteiro

AU - Del’Aquilla, Marco Antonio Gomes

AU - Mcguire, Philip

AU - Rohde, Luis Augusto

AU - Miguel, Euripedes Constantino

AU - Bressan, Rodrigo Affonseca

AU - Jackowski, Andrea Parolin

PY - 2018/11/3

Y1 - 2018/11/3

N2 - The family environment in childhood has a strong effect on mental health outcomes throughout life. This effect is thought to depend at least in part on modifications of neurodevelopment trajectories. In this exploratory study, we sought to investigate whether a feasible resting-state fMRI metric of local spontaneous oscillatory neural activity, the fractional amplitude of low-frequency fluctuations (fALFF), is associated with the levels of children’s family coherence and conflict. Moreover, we sought to further explore whether spontaneous activity in the brain areas influenced by family environment would also be associated with a mental health outcome, namely the incidence of behavioral and emotional problems. Resting-state fMRI data from 655 children and adolescents (6–15 years old) were examined. The quality of the family environment was found to be positively correlated with fALFF in the left temporal pole and negatively correlated with fALFF in the right orbitofrontal cortex. Remarkably, increased fALFF in the temporal pole was associated with a lower incidence of behavioral and emotional problems, whereas increased fALFF in the orbitofrontal cortex was correlated with a higher incidence.

AB - The family environment in childhood has a strong effect on mental health outcomes throughout life. This effect is thought to depend at least in part on modifications of neurodevelopment trajectories. In this exploratory study, we sought to investigate whether a feasible resting-state fMRI metric of local spontaneous oscillatory neural activity, the fractional amplitude of low-frequency fluctuations (fALFF), is associated with the levels of children’s family coherence and conflict. Moreover, we sought to further explore whether spontaneous activity in the brain areas influenced by family environment would also be associated with a mental health outcome, namely the incidence of behavioral and emotional problems. Resting-state fMRI data from 655 children and adolescents (6–15 years old) were examined. The quality of the family environment was found to be positively correlated with fALFF in the left temporal pole and negatively correlated with fALFF in the right orbitofrontal cortex. Remarkably, increased fALFF in the temporal pole was associated with a lower incidence of behavioral and emotional problems, whereas increased fALFF in the orbitofrontal cortex was correlated with a higher incidence.

KW - Development

KW - Family environment

KW - Neuroimaging

KW - Psychopathology

KW - Resting state

UR - https://www.scopus.com/pages/publications/85055980876

U2 - 10.1007/s00787-018-1240-y

DO - 10.1007/s00787-018-1240-y

M3 - Article

AN - SCOPUS:85055980876

SN - 1018-8827

JO - European Child and Adolescent Psychiatry

JF - European Child and Adolescent Psychiatry

ER -